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 Compositions for use in embolizing blood vessels

Details
Inventors: Greff, Richard J.; Jones, Michael L.; Evans, Scott;
Assignee: Micro Therapeutics, Inc. (San Clemente, CA)
Primary Examiner: Niland; Patrick
Assistant Examiner:
Attorney, Agent or Firm: Burns, Doane, Swecker & Mathis, L.L.P.

Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise an ethylene vinyl alcohol copolymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.

DETAILED DESCRIPTION OF THE INVENTION This invention is directed to specific embolizing compositions comprising a specific embolizing agent, specific contrast agents and a biocompatible solvent.
Prior to discussing this invention in further detail, the following terms will first be defined: The term "embolizing" as used in conjunction with "embolizing compositions" and "embolizing agents" refers to a process wherein a material is injected into a blood vessel which thereafter fills or plugs the blood vessel and/or encourages clot formation so that blood flow through the vessel ceases.
The embolization of the blood vessel is important in preventing/controlling bleeding (e.
g.
, organ bleeding, gastrointestinal bleeding, vascular bleeding, bleeding associated with an aneurysm) or to ablate diseased tissue (e.
g.
, tumors, etc.
) by cutting off its blood supply.
The term "ethylene vinyl alcohol copolymers" refers to copolymers comprising residues of both ethylene and vinyl alcohol monomers.
Small amounts (e.
g.
, less than 5 mole percent) of additional monomers can be included in the polymer structure or grafted thereon provided such additional monomers do not alter the embolizing properties of the composition.
Such additional monomers include, by way of example only, maleic anhydride, styrene, propylene, acrylic acid, vinyl acetate and the like.
Ethylene vinyl alcohol copolymers used herein are either commercially available or can be prepared by art recognized procedures.
Preferably, the ethylene vinyl alcohol copolymer composition is selected such that a solution of 6 weight percent of the ethylene vinyl alcohol copolymer, 35 weight percent of a tantalum contrast agent in DMSO has a viscosity equal to or less than 60 centipoise at 20.
degree.
C.
As is apparent to one skilled in the art, with all other factors being equal, copolymers having a lower molecular weight will impart a lower viscosity to the composition as compared to higher molecular weight copolymers.
Accordingly, adjustment of the viscosity of the composition as necessary for catheter delivery can be readily achieved by mere adjustment of the molecular weight of the copolymer composition



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