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Endoprosthetic device with therapeutic compound
| Details |
Inventors: Phan, Loc; Stertzer, Simon; Froix, Michael;
Assignee: Quanam Medical Corporation (Santa Clara, CA)
Primary Examiner: Buiz; Michael
Assistant Examiner: Truong; Kevin
Attorney, Agent or Firm: Mohr; Judy M., Dehlinger; Peter J.
An endoprosthetic device for insertion at a vascular site is described. The device is composed of a structural member carrying a polymer member having an embedded therapeutic compound. The polymer member is formed of a shape-memory polymer for expansion upon exposed to a selected stimulus. The structural member is designed for coexpansion with the polymer member when the device is exposed to the stimulus. |
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DETAILED DESCRIPTION Accordingly, it is an object of the invention to provide a stent which overcomes the above-mentioned problems.
In one aspect, the invention includes, a drug-delivery endoprosthetic device for insertion at a vessel target site via catheter placement at the site.
The device includes a shape-memory polymer member capable of expanding from a contracted state to a stable, radially expanded state when the polymer member is exposed to a selected stimulus.
The polymer member has an embedded drug for release from the member when it is placed at the target site.
The device also includes a structural member on which the polymer member is carried, and is capable of coexpansion with the polymer member when the device is exposed to the stimulus.
The device can be delivered from a catheter, with the structural and polymer members in their contracted states, and is adapted to be held in a vessel at the target site by radial pressure against the wall of the vessel, with the structural and polymer members in their expanded states.
In one embodiment, the polymer member is composed of a shape-memory polymer responsive to a thermal stimulus at a temperature between about 25.
degree.
-100.
degree.
C.
The polymer member is coextensive with the structural member, or, in other embodiments, the polymer member encases the structural member and, in its contracted state, is effective to restrain the structural member in its contracted state.
In one embodiment, the thermally-responsive polymer member is formed of a memory polymer having a thermally-activated polymer-state transition which is a melting point of the polymer; a glass-transition of the polymer; a liquid crystal transition; or a local mode molecular transition.
Such a polymer can be an acrylate-containing or a methacrylate-containing polymer.
In another embodiment, the structural member expands in response to a heat stimulus or radial force.
Preferably, such a structural member composed of a metal or alloy such as Nitinol, stainless steel, titanium, tantalum, cobalt, platinum, and iridium
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Obesity Surgery 
