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 Methods for treating urinary incontinence in mammals

Details
Inventors: Wallace, George; Greff, Richard J.;
Assignee: Micro Therapeutics, Inc. (San Clemente, CA)
Primary Examiner: Lacyk; John P.
Assistant Examiner: Kearney; Rosiland
Attorney, Agent or Firm: Burns, Doane, Swecker & Mathis, L.L.P.

Disclosed are methods for treating urinary incontinence in a mammal wherein a composition comprising a biocompatible polymer, a biocompatible solvent, and a contrast agent is delivered to the periurethral tissue of the mammal.

DETAILED DESCRIPTION OF THE INVENTION This invention is directed to methods for treating urinary incontinence in mammals, which methods comprise delivering a composition comprising a biocompatible polymer, a biocompatible solvent, and a contrast agent to the periurethral tissue of the mammal.
Prior to discussing this invention in further detail, the following terms will first be defined: The term "urinary incontinence" refers to the involuntary leakage of urine through the urethra from the bladder.
Methods for diagnosing urinary incontinence are well known to those skilled in the relevant art.
Such methods included, for example, video urodynamics and pad tests as described by Moore, et al.
.
sup.
12 The term "periurethral tissue" refers to the tissue surrounding the urethra.
As is understood in the art, the urethra is an orifice attached at its base to the bladder and permits discharge of urine from the bladder.
Preferably, the polymeric compositions of the present invention are delivered to the periurethral tissue at or near the base of the urethra.
The term "biocompatible polymer" refers to polymers which, in the amounts employed, are non-toxic, non-peptidyl, non-migratory, chemically inert, and substantially non-immunogenic when used internally in the mammal and which are substantially insoluble in the periurethral tissue.
The biocompatible polymers do not substantially decrease in volume over time and, since the polymer forms a solid inert mass, it does not migrate to distant organs within the body.
Suitable biocompatible polymers include, by way of example, cellulose acetates.
sup.
18-20 (including cellulose diacetate.
sup.
21), ethylene vinyl alcohol copolymers.
sup.
22,23, polyalkyl(C.
sub.
1 -C.
sub.
6) acrylates, polyalkyl alkacrylates wherein the alkyl and the alk groups contain no more than 6 carbon atoms, polyacrylonitrile and the like.
Additional biocompatible polymers are disclosed in U.
S.
patent application Ser.
No.
08/655,822 entitled "Novel Compositions for Use in Embolizing Blood Vessels" which application is incorporated herein by reference in its entirety



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