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| Second stage scuba diving regulator |
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| Microwave hyperthermia probe |
| OF THE PREFERRED EMBODIMENT Referring to FIG. 1, a microwave probe 10 is constructed from a ... |
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| Steerable catheter with rotatable tip electrode and method of use |
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| Apparatus for manually forming containers into portable packs |
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| External fixator for repairing fractures of distal radius and wrist |
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| Electrical connection device |
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Process and device to reduce interstitial fluid pressure in tissue
| Details |
Inventors: DiResta, Gene R.; Lee, Jongbin; Arbit, Ehud;
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Primary Examiner: Maglione; Corrine M.
Assistant Examiner:
Attorney, Agent or Firm: White; John P.
A method and apparatus are provided for reducing interstitial fluid pressure in tissues, particularly in tumors, by applying suction to the interior of the tissue. The method comprises inserting into the tissue one or more needle-like, elongated tubes, each having at least one hole at or near the end that is inserted into the tissue and each having means to apply suction to the protruding end. The reduced pressure produced inside the tissue by this method is useful to: facilitate penetration by drugs and therapeutic macromolecules into the tissue; enhance radiation treatment of tumors by increasing the oxygen supply in the tumor; and remove fluid to reduce edema in tissues, e.g. brain edema. Means may be provided to measure the pressure within the tissue and to use this measurement to control the suction applied to the tissue through the tubes. |
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DETAILED DESCRIPTION An object of the present invention is to provide a new mechanical approach to decrease IFP, and/or facilitate clearing of interstitial fluid when such clearing is impaired (e.
g.
, brain edema, lymph edema).
According to the present invention, an artificial lymphatic system (ALS) is employed to reduce IFP within tissue, particularly tumors.
The object is to enhance convection through the tumor by creating a new pressure gradient within the tumor.
For reducing IFP in tumors, a suction force is used to create a negative pressure (less than the IFP) inside the tumor.
The method and apparatus of this invention will be suitable for reducing IFP for inoperable tumors (including brain and liver tumors) as well as operable tumors, and thereby enhance penetration of drugs, in particular macromolecules (e.
g.
MoAbs), into tumors.
It is another object of the present invention to reduce interstitial fluid pressure in tumors, to thereby enable blood to be drawn into the tumor, which blood will transport oxygen into the tumor and enhance radiation treatment of the tumor.
It is another object of the present invention to provide an adjunct treatment to chemotherapy involving large macromolecules.
According to one aspect of the present invention, a process for reducing interstitial fluid pressure in tissue is provided, comprising placing an aspiration device within tissue, and applying, to the aspiration device, suction having a pressure value less than the interstitial fluid pressure, to thereby reduce the interstitial fluid pressure within the tissue.
According to another aspect of the present invention, an apparatus for reducing interstitial fluid pressure in tissue is provided, comprising an aspiration device having a plurality of aspiration tubes connected to a manifold means, each of said tubes having a plurality of aspiration holes, and means for connecting the manifold means to a suction source for creating suction inside the aspiration tubes, having a pressure value less than the interstitial fluid pressure to thereby reduce the fluid pressure inside the tissue when the tubes are located in the tissue
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