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 Tissue injectable composition and method of use

Details
Inventors: Lawin, Timothy P.; Williams, Jeffrey M.;
Assignee: Advanced UroScience, Inc. (St. Paul, MN)
Primary Examiner: Kishore; Gollamudi S.
Assistant Examiner: Webber; Pamela S.
Attorney, Agent or Firm: Moore & Hansen

An improved biocompatible composition consisting of physiologically stable microparticles carried in a lubricative suspension, solution, other fluid or gel is presented. The composition is intended to be delivered into the body through a small-bore needle, cannula, or catheter and to a tissue site for the purpose of augmenting the tissue site and surrounding area, thereby correcting a defect, filling a void, or strengthening the support structures of the tissue. The particles are a hard, metallic substance and are carbon-coated.

DETAILED DESCRIPTION What is claimed is: 1.
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein the particles are substrate particles with a carbon coating and have an average, transverse cross-sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
2.
The composition of claim 1 wherein: said substrate particles are a metallic substance.
3.
The composition of claim 1 wherein: the substrate particles are selected from the group comprising stainless steel, titanium and titanium alloys, and their oxides.
4.
The composition of claim 1 wherein: said carbon coating is isotropic carbon.
5.
The composition of claim 1 wherein: said substrate particles are zirconium oxide.
6.
The composition of claim 4 wherein: said isotropic carbon coating is low temperature isotropic (LTI), pyrolyric carbon.
7.
The composition of claim 6 wherein: said substrate particles are zirconium oxide.
8.
The composition of claim 4 wherein: said isotropic carbon coating is ultra low temperature isotropic carbon which is vapor deposited.
9.
The composition of claim 1 wherein: said carbon coating is pyrolyric, isotropic carbon.
10.
The composition of claim 8 wherein: said substrate particles are gold or silver.
11.
The composition of claim 1 wherein: said carbon coating is a smooth, surface film.
12.
The composition of claim 4 wherein: said coating is a smooth, surface film.
13.
The composition of claim 4 wherein: said carbon coating is vitreous carbon.
14.
The composition of claim 11 wherein: said substrate particles are zirconium oxide.
15.
The composition of claim 4 wherein: said substrate particles are of rounded shape and said dimension is between 200 microns and 500 microns.
16.
The composition of claim 1 wherein: the substrate particles are radiopaque.
17.
The composition of claim 1 wherein: the carrier is a solution, suspension or gel of polysaccharides



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