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| What is claimed is: 1. A system for securing a prosthesis to the human body, comprising a device ... |
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| Bristles for a hairbrush |
| OF PREFERRED EMBODIMENTS A bristle of the present invention (FIG. 1) includes a bristle base 3 and ... |
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| Electric tongue cleaner |
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| Catheter exchange system |
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| Vein and tubing passer surgical instrument |
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| Apparatus and method for determining the tension on a ligament graft |
| What is claimed is: 1. An instrument for determining the variation in tension of a ligament graft ... |
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| Drain inserter |
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| Means for improving biocompatibility of implants, particularly of vascular grafts |
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| Two piece balloon protector |
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Tissue repair matrix
| Details |
Inventors: Yamamoto, Ronald K.; Kwan, Michael K.; Pacetti, Stephen D.;
Assignee: DePuy AcroMed, Inc. (Raynham, MA)
Primary Examiner: Willse; David H.
Assistant Examiner: Blanco; Javier G.
Attorney, Agent or Firm: Beyer, Weaver & Thomas, LLP.
A porous three-dimensional tissue repair matrix is provided which is biodegradable. The matrix is preferably formed from mineralized collagen where the mineral comprises particulate calcium phosphate immobilized in the matrix. |
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DETAILED DESCRIPTION What is claimed is: 1.
A method of repairing fibrous tissue or cartilage comprising the step of introducing to a target site of repair, a composition comprising an effective amount of a porous, biodegradable three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking, sufficient to promote new fibrous tissue or cartilage formation.
2.
A method of repairing fibrous tissue, cartilage or bone comprising the steps of: (a) introducing a delivery vehicle to a target site or repair, said vehicle containing a porous, biodegradable, three-dimensionally fixed matrix having shape memory comprising insoluble mineralized biopolymer fibers and a water-soluble binder which is rendered insoluble by cross-linking, said matrix being in a compressed state relative to the initial size, shape, and porosity of said matrix; and (b) releasing said matrix from said delivery vehicle whereby said matrix returns to said initial size, shape, and porosity.
3.
A method according to claim 2, wherein said matrix returns to said initial size, shape and porosity without loss of a substantial amount of said fibers and binder.
4.
A method according to claim 1 or 2 wherein said matrix further comprises an additive.
5.
A method according to claim 4 wherein said additive comprises a drug.
6.
A method according to claim 5 wherein said drug comprises an antibiotic.
7.
A method according to claim 4 wherein said additive comprises a growth factor.
8.
A method according to claim 1 or 2 wherein said matrix further comprises marrow.
9.
A method according to claim 1 or 2 wherein said binder is selected from the group consisting of soluble collagen, gelatin, polylactic acid, polyglycolic acid, copolymers of lactic and glycolic acid, polycaprolactone, carboxymethylcellulose, cellulose esters, dextrose, dextran, chitosan, hyaluronic acid, ficol, chondroitin sulfate, polyvinyl alcohol, polyacrylic acid, polypropylene glycol, polyethylene glycol, water soluble polyacrylates and water soluble polymethacrylates
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