 Inks, particularly for ink printing |
| What is claimed is: 1. An ink containing as stabilizer at least one compound of formula I ##STR28## ... |
|
| Waterfast inks via cyclodextrin inclusion complex |
| What is claimed is: 1. A liquid ink suitable for ink-jet printing, comprising, by weight: (a) a ... |
|
| Light-sensitive positive working composition containing a pisolfone compound |
| What is claimed is: 1. A positive working light-sensitive composition which comprises: (a) 10 to 95%... |
|
| Light-stabilized ink composition |
| What is claimed is: 1. A method of stabilizing an ink jet print against the deleterious effects of ... |
|
| High molecular weight colloids which control bleed |
| What Is claimed Is: 1. A process for controlling color bleed in inks employed in thermal ink-jet ... |
|
| Reusable hidden indicia printed sheet |
| I claim: 1. A reusable hidden indicia printed sheet comprising a paper containing a first color-... |
|
| Smoking compositions containing a flavorant-release additive |
| What is claimed is: 1. A smoking composition comprising an admixture of (1) combustible filler ... |
|
| Thermally developable light-sensitive layers containing photobleachable sensitizers |
| OF THE INVENTION Thermally developable imaging systems described in U.S. Pat. Nos. 4,460,677 and 4,... |
|
| Chromatographic stationary supports |
| This invention therefore relates to a polyhydroxylated material comprising an organic or inorganic ... |
|
|
Catechol carboxylic acids
| Details |
Inventors: Carson, Matthew; Han, Ru-Jen L.; LeMahieu, Ronald A.;
Assignee: Hoffmann-La Roche Inc. (Nutley, NJ)
Primary Examiner: Shippen; Michael L.
Assistant Examiner:
Attorney, Agent or Firm: Gould; George M., Leon; Bernard S., Isgro; William G.
The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R.sub.1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R.sub.2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2, R.sub.3 is hydrogen, lower alkyl or amino, R.sub.4 is hydrogen, lower alkyl, halogen or amino A is ##STR4## wherein, R.sub.5 is hydrogen or acyl, R.sub.6 is hydrogen, halogen, lower alkyl, aryl or cycloalkyl, and R.sub.7 and R.sub.8, independently, are hydrogen, lower alkyl or halogen, or A is ##STR5## wherein, R.sub.5 is hydrogen or acyl, R.sub.9 is hydrogen, lower alkyl, R.sub.10 is hydrogen, lower alkyl or halogen, R.sub.11 is hydrogen, lower alkyl, cycloalkyl or halogen, m is 0 or 1, n is an integer of 2-10, provided, that no more than one of R.sub.1 or R.sub.2 can be hydroxy, alkanoyloxy or ##STR6## and when R is hydrogen, salts thereof with pharmaceutically acceptable bases or when R is --(CH.sub.2).sub.n --N--(lower alkyl).sub.2, salts thereof with pharmaceutically acceptable acids. The compounds of formula I are useful as agents for the treatment of inflammatory diseases such as arthritis, inflammatory bowel disease such as colitis, cardiovascular diseases such as myocardial ischemia, skin diseases such as psoriasis by topical administration, and bronchopulmonary diseases such as asthma. |
|
DETAILED DESCRIPTION OF THE INVENTION As used herein, the term "lower alkyl" denotes a straight or branched chain saturated hydrocarbon containing 1 to 7 carbon atoms, for example, methyl, ethyl, propyl, isopropyl, butyl, t-butyl, neopentyl, pentyl, heptyl, and the like.
Branched chain saturated hydrocarbons are preferred for R.
sub.
6, R.
sub.
9 and R.
sub.
11.
The term "halogen" denotes all the halogens, that is, bromine, chlorine, fluorine, and iodine.
The term "aryl" denotes phenyl or phenyl bearing one or two substituents independently selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino and di-lower alkylamino.
The term "acyl" denotes an "alkanoyl" group derived from an aliphatic carboxylic acid of 1 to 7 carbon atoms, for example, formyl, acetyl, propionyl, and the like; and an "aroyl" group derived from an aromatic carboxylic acid, for example, benzoyl and the like.
The term "alkanoyloxy" denotes a group derived from an aliphatic carboxylic acid of 1 to 7 carbon atoms, for example, formyloxy, acetoxy, propionyloxy, and the like.
The term "cycloalkyl" denotes preferably a cyclic hydrocarbon of 3 to 6 carbon atoms which may be unsubstituted or substituted by lower alkyl and most preferably of 5 to 6 carbon atoms, for example, cyclopropyl, cyclopentyl, cyclohexyl or the like.
The invention relates to catechol carboxylic acid derivatives of the formula ##STR13## wherein R.
sup.
1 is ##STR14## acetyl, hydrogen, hydroxy or alkanoyloxy, R.
sub.
2 is ##STR15## hydroxy, hydrogen or alkanoyloxy, wherein R is hydrogen, lower alkyl or --(CH.
sub.
2).
sub.
n N (lower alkyl).
sub.
2, R.
sub.
3 is hydrogen, lower alkyl or amino, R.
sub.
4 is hydrogen, lower alkyl, halogen or amino, A is ##STR16## wherein R.
sub.
5 is hydrogen or acyl, R.
sub.
6 is hydrogen, halogen, lower alkyl, aryl or cycloalkyl, and R.
sub.
7 and R.
sub.
8, independently, are hydrogen, lower alkyl or halogen, or A is ##STR17## wherein R.
sub.
5 is hydrogen or acyl, R.
sub.
9 is hydrogen or lower alkyl, R
|
| Related patents |
|
|
Stabilization of ink compositions
We claim: 1. An ink composition, comprising: (A) 25 to 35 weight percent, based on the total weight of said composition, of a water-dispersible polymer having ...
|
|
|
Dyeing method
What is claimed is: 1. A method for the continuous dyeing or printing of a cellulose-containing textile substrate which comprises continuously applying to said substrate ...
|
|
|
Photoinitiators for photopolymerization of unsaturated systems
We claim: 1. A process for the photopolymerization of an ethylenically unsaturated compound or a system containing said compound, comprising exposing said compound or ...
|
|
|
Direct dry negative color printing process and composition
I claim: 1. A direct negative color photosensitive composition comprising a binder containing a plurality of grains of semiconductor each having absorbed on its surface ...
|
|
|
Chalcone derivatives and process for producing the same
OF THE INVENTION The novel chalcone derivatives having at least one tetrahydropyranyloxy group which the present invention provides, for example, those compounds in ...
|
|
|
Recording materials for ink-jet printing
What is claimed is: 1. A recording material for ink jet printing comprising a carrier having a surface which can be printed on or a carrier coated on one side with a ...
|
|
|
Dyeing of polyamide substrates with an organic N-nitroso-hydroxylamine as light stabilizer
We claim: 1. A process for dyeing a polyamide substrate from an aqueous bath with a suitable dye and with a copper complex as light stabilizer for the dyed polyamide, ...
|
|
|
Radiation-sensitive mixture and use thereof
We claim: 1. A radiation-sensitive mixture which is suitable for preparing a polyimide, a polyisoindoloquinazolinedione, a polyoxazinedione, a polyquinazolinedione or a ...
|
|
|
Novel bis-onium salts and the use thereof as photoinitiators
What is claimed is: 1. A composition of matter comprising a material curable by a Bronsted acid, and a bis-sulfonium, -selenonium, -arsonium, -ammonium, or -phosphonium ...
|
|
|
Light-stabilized ink compositions
What is claimed is: 1. A method of stabilizing an ink jet print against the deleterious effects of light which comprises preparing an aqueous solution containing at ...
|
|
|
Quantum Computing 
