Chromatographic stationary supports

DETAILED DESCRIPTION This invention therefore relates to a polyhydroxylated material comprising an organic or inorganic backbone having a plurality of hydroxyl groups at its surface, which material has been modified by the direct covalent bonding to said backbone, at the former site of at least one of said hydroxyl groups, of a nucleophilic ligand.
This invention further relates to methods for preparing such materials comprising (a) reacting a polyhydroxylated polymeric material having a plurality of hydroxyl groups at its surface with a reagent effective to cleave the O--H bond of at least one of said hydroxyl groups and introduce through an --O-- linkage a moiety amenable to nucleophilic displacement; an (b) reacting the product of step (a) with a nucleophilic ligand.