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| Use of implanted ions to reduce oxide-nitride-oxide (ONO) etch residue and polystringers |
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Magnetic resonance imaging agents
| Details |
Inventors: Rajagopalan, Raghavan; Periasamy, Muthunadar P.;
Assignee: Mallinckrodt Medical, Inc. (St. Louis, MO)
Primary Examiner: Bond; Robert T.
Assistant Examiner:
Attorney, Agent or Firm: Rothwell, Figg, Ernst & Kurz
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with aminoalkylamide derivatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetraacetic acid ("EDTA") or other polyaminocarboxylic or cyclic polyaminocarboxylic chelating agents, These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal. |
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DETAILED DESCRIPTION OF THE INVENTION The complexing agents employed in this invention are derivatives of well-known polyaminocarboxylic acid chelating agents, such as DTPA and ethylenediaminetetraacetic acid ("EDTA") and cyclic polyaminocarboxylic acid chelating agents such as 1,4,7,10-tetraazacyclododecane N,N',N",N'"-tetra acetic acid ("DOTA").
In one class of these derivatives, free carboxylic acid groups of the chelating agent (those not involved in bond formation with the paramagnetic ion ) are converted to aminoalkylamide groups of the formula: ##STR12## For example, if the polyaminocarboxylic acid chelating agent is DTPA, and the paramagnetic ion is trivalent, two of the carboxylic acid groups will be derivatized to the aminoalkylamide form.
Likewise, if the paramagnetic ion is divalent, three of the carboxylic acid groups of DTPA or two of the carboxylic acid groups of EDTA will be derivatized to the aminoalkylamide form.
When these complexing agents are reacted with a divalent or trivalent paramagnetic ion, the resulting complexes are substantially non-ionic as evidenced by very low electrical conductivity.
Examples of types of aminoalkylamide derivatives useful as complexes include those wherein the aminoalkylamide group is ##STR13## wherein X is O, S or N, unsubstituted or substituted.
In a preferred embodiment, the aminoalkylamide group is a morpholinoalkylamide.
An alternative class of compounds encompassed by this invention, includes cyclic polyamino carboxylic acid chelating agents, such as DOTA and TRITA and represented by the general formula: ##STR14## In these agents, free carboxylic acid groups are converted to ##STR15## wherein R.
sup.
2' is either (CH.
sub.
2 CH.
sub.
2 O).
sub.
p --R.
sup.
3' or ##STR16## As with the first class of agents described above, if the paramagnetic ion is trivalent, one of the carboxylic acid groups will be derivatized to the aminoalkylamide form, and if the paramagnetic ion is divalent, two of the carboxylic acid groups will be derivatized.
Examples of types of derivatives useful as complexes include those wherein the amino alkylamide group is: ##STR17## In a preferred embodiment, the aminoalkylamide group is morpholinoalkylamide
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