Methods for the preparation of controlled gastric residence time medicament formulations

DETAILED DESCRIPTION What is claimed is: 1.
A method of preparing a controlled gastric residence medicament formulation comprising: a.
applying a first coating to a medicament core of a non-toxic, water hydratable and water permeable, polymeric film comprising a ratio of eight parts of a prepolymer of the formula: ##STR2## wherein R.
sub.
1 and R.
sub.
2 are independently, hydrogen, hydroxy, halo having an atomic weight of 19 to 36, alkyl having 1 to 16 carbon atoms, substituted aralkyl or SO.
sub.
3 H; polymerized with alkylvinylether having 1 to 16 carbon atoms, alkene, aryl, aralkyl, or substituted aralkyl and represents an average polymer molecular weight of from 100,000 to 5,000,000; said prepolymer cross-linked with from about 0.
15 to about 2 parts of a cross-linking agent selected from the group consisting of alkylene diol, polyalkylene glycols, polyoxyethylene sorbitan ethers, diamines, and triols, about 1 to about 10 parts of plasticizer selected from the group consisting of glycerol triacetate, ethylacetate, diethylphthalate, dibutyl phthalate, di(n-butyl)sebacate, propylene glycol, polyethylene glycol, glycerin, sorbitol and mixtures thereof; b.
treating the polymeric film coated core with a volatile amine vapor for about 5 minutes to about 24 hours; c.
coating the amine treated polymeric film core with a second coating of the polymeric film of step (a); and d.
maintaining the coated medicament formulation at a relative humidity of from about 30 to about 95 percent at a temperature of from about 10.
degree.
to about 90.
degree.
C.
for about 4 to 200 hours to crosslink said second coating.
2.
The method according to claim 1, wherein the volatile amine is selected from the group consisting of anhydrous ammonia, methyl amine, or ethyl amine.
3.
The method according to claim 2, wherein the volatile amine is anhydrous ammonia.
4.
The method according to claim 1, wherein said cross-linking agent is from about 0.
15 to 1.
0 parts and said plasticizer is from about 4 to 5 parts.
5.
The method according to claim 4, wherein said formulation is cross-linked at from about 20