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Asymmetric semipermeable membrane for the treatment of biological fluids
| Details |
Inventors: Angleraud, Rene; Brun, Claude;
Assignee: Hospal Industrie (Meyzieu, FR)
Primary Examiner: Spear; Frank
Assistant Examiner:
Attorney, Agent or Firm: Bell, Seltzer, Park & Gibson
An asymmetric semipermeable membrane and processes for the manufacture thereof are disclosed. The membrane comprises at least one hydrophobic polymer and at least one copolymer based on acrylonitrile, at least one sulphonic monomer which is optionally salified, and optionally at least one non-ionic, ionizable, olefinically unsaturated monomer. The membrane is useful in the treatment of biological fluids such as plasma or blood, especially using plasmapheresis, or with the aid of an artificial kidney using hemodialysis and/or ultrafiltration. |
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DETAILED DESCRIPTION An objective of the present invention is to provide an improved semipermeable membrane suitable for the treatment of biological fluids which are intended to be recirculated to a human or animal body.
Another objective of the present invention is to provide a semipermeable membrane having excellent performance characteristics, biocompatibility, and which also does not have the defects of the prior art membranes.
The term "semipermeable" is intended to mean good water permeability, and selective permeability to molecules of a size determined according to the envisaged medical application, e.
g.
plasmapheresis or hemodialysis.
For example, in hemodialysis the membrane must be permeable to metabolites such as urea, creatinine, "average molecules," and to the solutes of relatively higher molecular weight.
It must remain impermeable to blood proteins whose molecular weight is higher than or equal to that of albumin.
The term "biocompatibility" is intended to mean a biologically compatible membrane which produces little or no change in the biological parameters.
More precisely, a membrane is biocompatable if it is inert with respect to the two main defense mechanisms of an organism, namely hemostasis and immunity.
Hemostasis provides the organism with protection against the loss of blood, inter alia, caused by coagulation which is triggered when the blood comes into contact with a thrombogenic surface.
Another objective of the present invention is to provide a semipermeable membrane having excellent mechanical properties.
Yet another objective of the present invention is to provide a semipermeable membrane which retains its characteristics, particularly its rigidity and dimensional stability, when it changes from the dry state to the wet state or vice versa, and when it is stored in the dry state, without the necessity of any special, physical or chemical treatment.
Yet another objective of the present invention is to provide a semipermeable membrane which is substantially non-toxic
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