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Method and device for long-term delivery of drugs
| Details |
Inventors: Lee, Clarence C.;
Assignee: C.R. Bard, Inc. (Murray Hill, NJ)
Primary Examiner: Azpuru; Carlos A.
Assistant Examiner:
Attorney, Agent or Firm: Jones & Askew
The present invention is an implantable device that is capable of delivering a therapeutic agent to a tissue or organ over a long period of time. The implantable device is especially suited for treating tissues and organs that are comprised of smooth muscle. The implantable device can deliver either a single therapeutic agent or a plurality of therapeutic agents to the tissue or organ at zero order kinetics. |
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DETAILED DESCRIPTION The present invention is a device and method for the long-term local delivery of a therapeutic agent to a tissue or organ.
The present invention includes a device comprising a container with a biodegradable matrix therein.
The biodegradable matrix is admixed with a therapeutic agent.
The container can be implanted into a tissue and will deliver a desired therapeutic agent over a period of months to years.
More particularly, the present invention is an implant device for the long-term delivery of a therapeutic agent to a tissue or organ, comprising a container for implantation within the tissue or organ, a therapeutic agent contained within the container; and means associated with at least one of the container and the therapeutic agent for controlling the rate of release of the therapeutic agent from the container into the tissue or organ such that the therapeutic agent is released at a rate of between approximately 0.
1 .
mu.
g to approximately 12 mg/day over a period of at least one month.
In a preferred embodiment, the container is a cylinder with at least one opening to the tissue in which the cylinder is implanted.
The cylinder can be manufactured from silicone, stainless steel, titanium or other types of medical/surgical grade plastics or metals.
Plastics that can be used in constructing the present invention include, but are not limited to, polyethylene, polypropylene and parylene.
The cylinder walls are impermeable to enzymes or other macromolecules and optionally are impermeable to water.
Macromolecules are defined herein as molecules with a molecular weight greater than approximately 10,000 Daltons.
In one aspect, the present invention is particularly suited for the administration of musculotropic or neurochemicals to smooth muscle tissues.
Tissues and organs that can benefit from the present invention include, but are not limited to, stomach, intestines, heart, uterine, bladder, ureter, urethra, sphincter muscles, and the esophagus.
In one embodiment, the present invention is designed to reduce or eliminate incontinence frequency with pure detrusor instability or with a combination of stress urinary incontinence and detrusor instability without any upper motor neuron lesion
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