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Method for quantifying specific compound
| Details |
Inventors: Ikeda, Shin; Yoshioka, Toshihiko; Nankai, Shiro; Tsutsumi, Haruhiro; Baba, Hideyuki; Tokuno, Yoshinobu;
Assignee: Matsushita Electric Industrial Co., Ltd. (Kadoma, JP)
Primary Examiner: Bell; Bruce F.
Assistant Examiner:
Attorney, Agent or Firm: McDermott, Will & Emery
A biosensor for quantifying a specific compound has a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter electrode formed on an insulating base plate; the biosensor detects the specific compound contained in a sample on the basis of an electrochemical response. In quantifying, the working electrode and the counter electrode are short-circuited before the voltage is applied therebetween. The short-circuiting eliminates measuring errors that may occur due to nonuniform dissolution of the reaction layer in a sample, and achieves highly reliable quantification of a specific compound. |
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DETAILED DESCRIPTION It is an object of the present invention to provide a method for quantifying a specific compound, which eliminates the above-mentioned deficiencies.
According to the present invention, there is provided a method for quantifying a specific compound, which uses a biosensor comprising a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter-electrode formed on an insulating base plate, and which detects the change in substance concentration caused by the reaction between the enzyme and the specific compound contained in a sample on the basis of an electrochemical response obtained when a voltage is applied between the working electrode and the counter electrode, characterized in that the working electrode and the counter electrode are short-circuited before the voltage is applied therebetween.
According to the present invention, there is also provided a quantifying method wherein the circuit between the working electrode and the counter electrode is alternately closed and opened a plurality of times before applying voltage between the working electrode and the counter electrode.
The present invention provides an apparatus for quantifying a specific compound, comprising: a biosensor including a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter electrode formed on an insulating base plate; means for supplying a sample solution containing a specific compound to the reaction layer of the biosensor; voltage application means for applying a predetermined voltage between the working electrode and the counter electrode of the biosensor; means for measuring a current flowing between the working electrode and the counter electrode to which the voltage is applied; means for short-circuiting the working electrode and the counter electrode before the voltage is applied between the working electrode and the counter electrode.
While the novel features of the invention are set forth particularly in the appended claims, the invention, both as to organization and content, will be better understood and appreciated, along with other objects and features thereof, from the following detailed description taken in conjunction with the drawings
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