Quinoline derivatives as antagonists of leukotriene D.sub.4

DETAILED DESCRIPTION We claim: 1.
A compound of the formula ##STR15## where: A is O or S; D is O, S, NR.
sub.
1, ##STR16## or a chemical bond E is a chemical bond or ##STR17## a is 0-2; b is 0-1; d is 1-5; e is 0-4; f is 0-5; n is 0-2; R is independently hydrogen, alkyl, hydroxy, alkoxy, carboxy, carbalkoxy, halo, nitro, haloalkyl, cyano or acyl; R' is independently hydrogen, alkyl, hydroxy, alkoxy, halo or haloalkyl; R.
sub.
1 is independently hydrogen, alkyl or aralkyl; R.
sub.
2 is --(CH.
sub.
2).
sub.
x --X; x is 0-3; X is hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aralkyl, hydroxy, alkoxy, aralkoxy, amino, mono-and di-alkylamino, aralkylamino, acylamino, carbamyl, carboxy, carbalkoxy, tetrazolyl or acylsulfonamido; vicinal R.
sub.
2 groups together may be --(CH.
sub.
2).
sub.
y --, where y is 1-4, thus forming a 3-6 membered ring; geminal R.
sub.
1 and R.
sub.
2 groups may together form a spiro substituent, --(CH.
sub.
2).
sub.
z --, where z is 2 to 5; geminal R.
sub.
1 or R.
sub.
1 and R.
sub.
2 groups may together form an alkylidenyl substituent, .
dbd.
CHR.
sub.
1 ; Z is --COOR.
sub.
1, CN, ##STR18## --OR.
sub.
1 tetrazolyl or substituted tetrazolyl where the substituent may be alkyl, carboxyalkyl or carbalkoxyalkyl; R.
sub.
3 is hydrogen, alkyl, haloalkyl, phenyl or benzyl; and pharmaceutically acceptable salts thereof.
2.
A compound according to claim 1 where: A is O or S; n is 0-1; a+b is 1; e+f is 0-5; R and R' are hydrogen, alkyl or alkoxy; R.
sub.
1 is hydrogen or alkyl; R.
sub.
2 is --(CH.
sub.
2).
sub.
x --X; x is 0-3; X is hydrogen or alkyl; and Z is --COOR.
sub.
1, --CN, ##STR19## or tetrazolyl.
3.
A compound according to claim 2 where: A is 0; n is 0; d is 1-3; and Z is --COOR.
sub.
1, --CN or tetrazolyl.
4.
A compound according to claim 3 where: a is 1; b is 0; and d is 1.
5.
A compound according to claim 3 where: a is 1; b is 0; and d is 2.
6.
A compound according to claim 3 where: a is 1; b is 0; and d is 3.
7.
A compound according to claim 3 where: D is O; and E is a chemical bond.
8.
A compound according to claim 3 where: D is S; and E is a chemical bond