DETAILED DESCRIPTION What is claimed is: 1.
A compound of the formulae ##STR32## and salts thereof, where [R, R.
sup.
1 and Z are as defined in claim 1] in R and R.
sup.
1 are hydrogen, lower alkyl, chloro, bromo, phenyl or x-substituted phenyl where x is lower alkyl, chloro, fluoro, or lower alkyl --O-- and Z is --CN, ##STR33## wherein Y is --OH, --NH.
sub.
2, --O-- lower alkyl or ##STR34## 2.
The compound of claim 1 having the name 6-[(5-butyl-3-carboxy-2-thienyl)amino]-3-pyridinecarboxylic acid and salts thereof.
Description:
The present invention relates to new oxo-pyrido[1,2-a]thienopyrimidine compounds that are useful as anti-allergy agents, intermediates in their production, methods for their production, pharmaceutical compositions containing said anti-allergy agents and methods for treating allergic conditions with said compositions.
More particularly, the invention relates to new oxo-pyrido[1,2-a]thienopyrimidine compounds of the formulae.
##STR1## and salts thereof, where R and R.
sup.
1 are hydrogen, lower alkyl, chloro, bromo, phenyl, or X-substituted phenyl where X is lower alkyl, chloro, fluoro, or lower alkyl--O-- and Z is ##STR2## wherein Y is --OH, --NH.
sub.
2, --O-- lower alkyl or ##STR3## The term "lower alkyl" is intended to mean a hydrocarbon moiety which may be straight, branched or cyclic in configuration having from one to six carbon atoms.
The term "salts" is intended to mean salts formed by the addition of a base with those compounds of the invention capable of forming a salt, such as those compounds containing a carboxy or tetrazole group.
Typical salts would be the sodium, potassium, calcium, ammonium, organic amino, magnesium, etc.
salt.
The preferred salts are relatively non-toxic, thus pharmaceutically acceptable salts, preferably the sodium salt.
Compounds of this invention may form acid addition salts with strong acids, such as hydrochloric acid.
The preferred compounds of the invention are those wherein R is hydrogen, lower alkyl or phenyl and R.
sup
|
TV Signal 
