 Receiving apparatus for receiving a BS-IF signal converted into a superhigh band or UHF band |
| We claim: 1. A receiving apparatus comprising: an input terminal for receiving an input signal ... |
|
| Data transmitting equipment |
| What is claimed is: 1. Data transmission equipment for transmitting data between a local equipment ... |
|
| Swimmer's wallet |
| The present invention provides a lightweight and economical waterproof wallet suitable for use by a ... |
|
| Coded health-care glove |
| The above disadvantages and drawbacks of prior health-care gloves are largely obviated by the ... |
|
| High resolution quadrilinear CCD imager with four channel to one channel multiplexing |
| OF THE INVENTION FIG. 1 of the present application shows a conventional prior art quadrilinear ... |
|
| Method and apparatus for remotely controlling an electrical appliance |
| According to the invention, an electrical appliance connected across an alternating current power ... |
|
| Video camera |
| It is an object of the invention to provide a video camera having a specific structural arrangement,... |
|
|
Pulsatile drug delivery device using stimuli sensitive hydrogel
| Details |
Inventors: Bae, You H.; Kim, Sung W.; Valuev, Lev I.;
Assignee: University of Utah (Salt Lake City, UT)
Primary Examiner: Thaler; Michael H.
Assistant Examiner: Polutta; Mark O.
Attorney, Agent or Firm: Thorpe, North & Western
A device for the dispensing of a biologically active material into the surrounding environment is disclosed which consists of at least one wall enclosing a compartment which contains a swollen stimuli sensitive hydrogel in which the biologically active material is entrained in solution. The hydrogel deswells or shrinks in response to contact by external physical or chemical stimuli releasing the biologically active material into the portion of the compartment previously occupied by the swollen hydrogel. The wall enclosing the compartment is rigid and contains means allowing the passage of the biologically active material from the compartment to the surrounding environment and also for transmitting the external stimuli to the swollen hydrogel in said compartment. The wall may contain orifices or be permeable to the active material and external stimuli depending upon the drug and the stimuli to be used. The hydrogel reversibly deswells, shrinks or contracts in response to stimuli, such as temperature, pH, ionic strength, glucose concentration or metabolites in the body and then reswells and reentrains active material not diffused from the compartment when the stimuli is removed. The wall may consist of one or more layers which, in combination, provide for the expeditious delivery of the active substance either through permeation through the wall or through orifices in the wall and also for the conducting of the external stimuli through the wall into the compartment to trigger the deswelling of the hydrogel. |
|
DETAILED DESCRIPTION It is an object of the present invention to provide a delivery system which enables the effective delivery of drugs entrained within a hydrogel, via a squeezing mechanism, in response to external or internal, physical Or chemical stimuli.
It is also an object of this invention to provide a drug delivery system from which the drug release from a hydrogel of zero or first-order kinetics is achieved in response to such stimuli.
A still further object of this invention is to provide a suitable structure for a self-regulating or externally modulated drug delivery system which gives a pulsatile release pattern from a hydrogel with a minimal lag time.
Another object of this invention is to provide a delivery system meeting the above objectives Which also results in a controlled basal release of drugs from a hydrogel in the absence of stimuli or at reduced signal strength.
Yet another object is to control the triggering stimuli for the drug release from a device with the same hydrogel by changing drug loading conditions.
An additional object of this invention is to provide a stimuli responsive drug delivery system from a hydrogel enabling relatively easy drug loading and recharging when the system is exhausted.
These and other objects may be obtained by means of a dispenser device which is composed of sponge-like porous or dense hydrogel, in solid or particulate form, contained Within the confines of a walled structure wherein the walls either contain dispensing orifice(s) or are permeable to the diffusion of the entrained biologically active agent Or drug.
Depending upon the drug and the stimuli to be used, the walls of the dispenser device may be either impermeable or permeable to chemicals that are stimuli to the swelling or expanding, or contracting or deswelling of the hydrogel.
The sponge-like porous hydrogel reversibly deswells, shrinks or contracts in response to stimuli, such as temperature, pH, ionic strength, glucose concentration, metabolites in the body, or other conditions that cause the hydrogel to contract
|
| Related patents |
|
|
Method for making late programmable read-only memory devices
It is, therefore, an object of this invention to provide a method of programming a ROM late in its manufacturing method without large ROMs needing expansion in size to ...
|
|
|
Method of fabricating trench cell capacitors on a semocondcutor substrate
It is hence a primary object of this invention to present a method of fabricating a trench cell capacitor with high aspect ratio precisely. It is a second object of this ...
|
|
|
Mouth held switch assembly
This invention is concerned with a mouth held electrical switch assembly and more particularly with an electrical switch assembly that can be actuated only by a clamping ...
|
|
|
Blood lancet
I claim: 1. A relatively flat blood lancet, having a handle portion and a tip portion having sharp edges, which portions are made of plastic in one piece, comprising: a ...
|
|
|
Signaling system
What is claimed is: 1. In a speech privacy transmission system, means for analyzing speech currents into component frequency band currents in a plurality of separate ...
|
|
|
Divisional operation system for obtaining a quotient by repeated subtraction and shift operations
An object of this invention is to provide a divisional operation system which has saved an extra operation to attain a high operation speed. To achieve the above object, ...
|
|
|
Image pickup apparatus with white balance control
This invention is made in view of the above stated problem of the prior art. It is therefore a principal object of this invention to provide an image pickup apparatus ...
|
|
|
Door jamb switch
In accordance with the present invention then, there is provided an improvement in electrical switches by which the foregoing contact alignment problem is minimized or ...
|
|
|
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** *** NO IMAGES AVAILABLE***
Description:...
|
|
|
Secure communication system
The present invention is embodied in a secure communication system consisting of a message source of plain text, signal manipulation means, a transmission medium for the ...
|
|
|
Television 
