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3 5-bis alkanoyl amino-2 4 6-triiodobenzyl esters
| Details |
Inventors: Singh, Baldev;
Assignee: Nano Systems L.L.C. (Collegeville, PA)
Primary Examiner: Geist; Gary
Assistant Examiner: Williams; Rosalynd A.
Attorney, Agent or Firm: Rudman & Balogh
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 2; R.sup.1 is H or alkyl containing from 1 to 4 carbon atoms' R.sup.2 is H, alkyl containing from 1 to 4 carbon atoms, aryl or heteroaryl; and R.sup.3 is alkyl containing from 1 to 18 carbon atoms. This invention further relates to novel contrast agents having the above structure wherein R.sup.1 is H and R.sup.2 and R.sup.3 are CH.sub.3 to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents. |
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DETAILED DESCRIPTION I claim: 1.
A compound having the structure: ##STR18## wherein: n is 2; R.
sup.
1 is H or alkyl containing from 1 to 4 carbon atoms; R.
sup.
2 is H, alkyl containing from 1 to 4 carbon atoms, aryl or heteroaryl wherein aryl is phenyl, tolyl or anthracene and heteroaryl is thiophene or benzofuran; and R.
sup.
3 is alkyl containing from 1 to 18 carbon atoms.
2.
The compound of claim 1 wherein R.
sup.
1 is H and R.
sup.
2 is CH.
sub.
3 .
3.
The compound of claim 1 wherein R.
sup.
3 is methyl.
4.
The compound having the structure: ##STR19## 5.
A method of medical x-ray diagnostic imaging the blood pool, liver, spleen, or lymph system of a mammal comprising administering to the mammal a contrast effective amount of a compound having the structure: ##STR20## wherein: n is 2; R.
sup.
1 is H or alkyl containing from 1 to 4 carbon atoms; R.
sup.
2 is H, alkyl containing from 1 to 4 carbon atoms, aryl or heteroaryl wherein aryl is phenyl, tolyl or anthracene and heteroaryl is thiophene or benzofuran; and R.
sup.
3 is alkyl containing from 1 to 18 carbon atoms.
6.
The method of claim 5 wherein R.
sup.
1 is H and R.
sup.
2 is CH.
sub.
3.
7.
The method of claim 5 wherein R.
sup.
3 is methyl.
8.
The method of claim 5 wherein the compound has the structure ##STR21## 9.
An x-ray contrast composition comprising the compound of claim 1.
10.
The x-ray contrast composition of claim 9 further including a pharmaceutically acceptable carrier.
11.
A method for medical x-ray diagnostic imaging which comprises administering to the body of a mammal a contrast effective amount of the x-ray contrast composition of claim 9.
Description:
FIELD OF INVENTION This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal employing particulate compounds as a contrast agent, and to certain novel compounds useful as contrast agents in x-ray contrast compositions and methods of diagnostic imaging.
BACKGROUND OF THE INVENTION X-ray imaging is a well known and extremely valuable tool for the early detection and diagnosis of various disease states in the human body
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