5-HT.sub.3 receptor antagonists for treatment of cough and bronchoconstriction

DETAILED DESCRIPTION I claim: 1.
A method of treatment of cough and/or bronchoconstriction in mammals, which method comprises the administration to the mammal in need of such treatment, an effective amount of a 5-HT.
sub.
3 receptor antagonist compound of formula (I) or a pharmaceutically acceptable salt thereof: X--CO--Y--Z-- (I) wherein X is a group of formula (a) ##STR4## wherein R.
sub.
a is selected from the group consisting of hydrogen, halogen or hydroxy; R.
sub.
1 is hydrogen and R.
sub.
2 is hydrogen or C.
sub.
1-4 alkyl, or R.
sub.
1 and R.
sub.
2 together are a bond; R.
sub.
3 is hydrogen or C.
sub.
1-6 alkyl; R.
sub.
4 is hydrogen or C.
sub.
1-6 alkyl, and R.
sub.
4 together with R.
sub.
2 maybe C.
sub.
2-7 polymethylene when R.
sub.
1 is hydrogen; Y is NH; Z is a group of formula (f) ##STR5## wherein n is 2 or 3; and R.
sub.
12 is methyl or ethyl.
2.
A method according to claim 1 wherein the compound of formula (I) is BRL 43694A which is N-(endo-9-methyl-9-azabicyclo-[3.
3.
1]non-3-yl)-1-methyl-indazole-3-carboxa mide monohydrochloride.
3.
A pharmaceutical composition for use in the treatment of cough and/or bronchoconstriction, which comprises an effective amount of a 5-HT.
sub.
3 receptor antagonist, as defined in claim 1, and a pharmaceutically acceptable carrier.
4.
A method of using a 5-HT.
sub.
3 receptor antagonist as defined in claim 1 in the preparation of a medicament, said method including the steps of providing an amount of the 5-HT.
sub.
3 receptor antagonist effective for the treatment of cough and/or bronchoconstriction in mammals, including humans, and admixing said effective amount of the 5-HT.
sub.
3 receptor antagonist with a pharmaceutically acceptable carrier.
5.
A method of use as defined by claim 4, wherein said treatment is for cough.
6.
A method of use as defined by claim 4, wherein said treatment is for bronchoconstriction.
7.
The composition as defined by claim 3 for use in the treatment of cough.
8.
The composition as defined by claim 3 for use in the treatment of bronchoconstriction.




Description:
This invention relates to a method of treatment of cough and/or bronchoconstriction in mammals, including humans, and to the use of compounds in the preparation of a medicament for the treatment of cough and/or bronchoconstriction