Acetylene amines and their use as vasodilators and antihypertensives

DETAILED DESCRIPTION OF THE INVENTION Compounds of the invention are of the following formula ##STR3## wherein Y is independently alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyloxy, alkanoylamino, amino, monoalkylamino, dialkylamino, hydroxy, halogen or cyano or methylenedioxy or ethylenedioxy at adjacent ring carbons; m is 0, 1, 2 or 3; R.
sup.
1 and R.
sup.
2 are independently hydrogen, alkyl ##STR4## R.
sup.
3 is hydrogen, alkyl or alkoxyalkyl n is 0, 1 or 2; R.
sup.
4 is hydrogen or alkyl; R.
sup.
5 is hydrogen, alkyl, cycloalkyl or alkyl substituted by amino, monoalkylamino, dialkylamino, hydroxy, cycloalkyl, alkoxy, phenyl or phenyl substituted by 1 to 3 Y groups; Alk is a straight chain alkylene of about 1 to 4 carbons; Ar is a phenyl, phenoxy, thiophenoxy or a 5- or 6-membered heterocyclic aromatic ring which rings may be substituted independently by one or more of alkyl, alkoxy, alkylthio, hydroxy, halogen, fluoroalkyl, amino or dialkylamino or by methylenedioxy at adjacent ring carbons; R.
sup.
6 is alkyl; and q is 0, 1 or 2 or 3 if Alk is alkylene of about 2 to 4 carbons, and the pharmaceutically acceptable acid addition salts and quarternary ammonium compounds thereof.
In particular, Y is alkyl of about 1 to 6 carbons such as methyl or ethyl; alkoxy of about 1 to 6 carbon atoms such as methoxy or ethoxy; alkylthio of about 1 to 6 carbons such as methylthio; alkylsulfinyl of about 1 to 6 carbons such as methylsulfinyl; alkylsulfonyl of about 1 to 6 carbons such as methylsulfonyl; alkanoyloxy of about 2 to 6 carbons such as acetoxy; alkanoylamino of about 2 to 6 carbons such as acetylamino; amino; monoalkylamino of about 1 to 6 carbons such as ethylamino; dialkylamino of about 2 to 12 carbons such as dimethylamino; hydroxy; halogen such as fluoro, chloro or bromo; cyano; or methylenedioxy or ethylenedioxy wherein the two oxygen atoms are attached to two adjacent carbons of the benzene ring.
Although the Y groups may be attached at any of the 4 open positions of the benzene ring, particularly preferred are compounds wherein the Y groups are attached at the 4- and/or 5-positions of the ring relative to the amino side chain with the acetylene moiety being at the 2-position