 Indole derivatives |
| We claim: 1. A compound of formula (I) ##STR11## wherein R.sup.1 and R.sup.2 each represents a ... |
|
| 4-(3-(4-Quinolyl)propyl)piperidines, their preparation and their use as medicines |
| What is claimed is: 1. A method for the treatment of a mammal afflicted with a disturbance in the ... |
|
| 1,2,4-Triazoles |
| What is claimed is: 1. A compound of the formula: ##STR5## and non-toxic salts thereof, wherein R.... |
|
| Combating pests with substituted 3,6-diphenyl-3,4-dihydro-2H-1,3,5-oxadiazine-2,4-diones |
| What is claimed is: 1. An oxadiazine derivative of the formula ##STR8## in which R.sup.1 represents ... |
|
| 3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran |
| We claim: 1. Compounds having the general formula (I) ##STR89## wherein R is C.sub.1 -C.sub.6 alkyl;... |
|
| Pharmaceutical compositions effective against coronary heart disease and hypertension |
| I claim: 1. A pharmaceutical composition useful in treating coronary heart disease or hypertension ... |
|
| Composition for removing adhesives from polymeric film and process for using same |
| What is claimed is: 1. A process for separating an adhesive polymeric resin, from a polymeric film, ... |
|
| Sustained release, and comfortable opthalmic composition and method for ocular therapy |
| What is claimed is: 1. An ophthalmic composition, comprising: a) at least one basic active; b) a ... |
|
| Bactericidal formulations for use in veterinary medicine |
| We claim: 1. A method of treating mycoplasmotic and bacterial infections in fowl which comprises ... |
|
|
Anti-bronchoconstriction 2-(4'-pyridinyl)-thiazole derivatives, composition, and method of use therefor
| Details |
Inventors: Sunday, Brooks R.; Witkowski, Joseph T.;
Assignee: Schering Corporation (Kenilworth, NJ)
Primary Examiner:
Assistant Examiner:
Attorney, Agent or Firm:
Certain 2-(4'-pyridinyl)-thiazoles additionally substituted in either the 4- or 5- position are bronchodilating agents. Methods for their preparation and use are disclosed. |
|
DETAILED DESCRIPTION We claim: 1.
A compound having the structural formula I ##STR4## wherein R is cyano, ##STR5## --C(.
dbd.
X)NHY wherein X is O, S or NH; and Y is hydrogen, hydroxy, alkyl having from 1 to 6 carbon atoms, or hydroxyalkyl having from 1 to 6 carbon atoms, and the pharmaceutically acceptable salts thereof; provided that N-methyl-2-(4'-pyridinyl)-thiazole-4-carboxamide ,2-(4'-pyridinyl)-thiazole-4-carboxamide, and 4-cyano-2-(4'-pyridinyl)-thiazole are excluded.
2.
The compounds defined in claim 1 having the structural formula ##STR6## and the pharmaceutically acceptable salts thereof.
3.
The compounds defined in claim 1 having the structural formula ##STR7## and the pharmaceutically acceptable salts thereof.
4.
The compounds defined in claim 1 having the names: 2-(4'-pyridinyl)-thiazole-4-thiocarboxamide; 2-(4'-pyridinyl)-thiazole-5-carboxamide; N-(2-hydroxyethyl)-2-(4'-pyridinyl)-thiazole-4-carboxamide; 2-(4'-pyridinyl)-thiazole-4-carboxamidoxime; 2-(4'-pyridinyl)-thiazole-4-carboxamidine; 2-(4'-pyridinyl)-4-(2-imidazolin-2-yl)-thiazole; and the pharmaceutically acceptable salts thereof.
5.
A pharmaceutical composition useful for treating bronchoconstriction in a mammal which comprises an antibronchoconstrictionally effective amount of a compound having structural formula I ##STR8## wherein R is cyano, ##STR9## or --C(.
dbd.
X)NHY wherein X is 0, S or NH; and Y is hydrogen, hydroxy, alkyl having from 1 to 6 carbon atoms, or hydroxyalkyl having from 1 to 6 carbon atoms, and the pharmaceutically acceptable salts thereof; provided that N-methyl-2-(4'-Pyridinyl)-thiazole-4-carboxamide, 2-(4'-pyridinyl)-thiazole-4-carboxamide, and 4-cyano-2-(4'-pyridinyl)-thiazole are excluded, in combination with a pharmaceutically acceptable carrier.
6.
A method for treating bronchoconstriction in a mammal which comprises administering an antibronchoconstrictionally effective amount of a compound having structural formula I ##STR10## in combination with a pharmaceutically acceptable carrier, wherein R is cyano, ##STR11## or --C(
|
| Related patents |
|
|
Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations
What is claimed is: 1. A pharmaceutical composition comprising in a vehicle suitable for enteral, parenteral, topical or ocular administration, at least one aromatic ...
|
|
|
Antioxidant-induced apoptosis in vascular smooth muscle cells
The invention is based on the discovery that, unlike other cell types, vascular smooth muscle cells which contribute to the development of arteriosclerosis are induced ...
|
|
|
Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors
In a method aspect, this invention relates to a method of treating the climacterium symptoms in a non-pregnant female or in a male mammal which comprises administering ...
|
|
|
Microbial hair tonic composition
We claim: 1. A microbial hair treatment composition comprising 10.sup.6 to 10.sup.8 cells/ml of cultured living Staphylococcus capitis and a suitable solvent. 2. The ...
|
|
|
Hair treating composition
OF THE INVENTION The formulation of 9 parts d-panthenyl ethyl ether and 1 part d-panthenol can be incorporated in hair conditioning or treating compositions in an ...
|
|
|
Hair cosmetic composition
We claim: 1. A composition of matter in the form of a solution, comprising: (a) a solvent including ethanol; (b) a hair-growing component which is at least one compound ...
|
|
|
Anti-thrombogenic, anti-microbial compositions containing heparin
OF THE INVENTION The compositions of the present invention are first dissolved in solvent mixtures that are co-solvents for the mixtures of non-volatile components and ...
|
|
|
Derivative-compound-conjugates and pharmaceutical compositions comprising same
OF THE INVENTION The introduction of molecules of diagnostic, prophylactic, or therapeutic interest across body surfaces and/or into cells requires the transversal of ...
|
|
|
Vincamine derivatives and process for the preparation of vincamine and derivatives thereof
Having now described our invention what we claim as new and desire to secure by Letters Patent is: 1. 20-Deethyl-apovincamine, having the formula: ##SPC7## under its ...
|
|
|
Naphthyridine derivatives and their use as anti-bacterials
What we claim is: 1. A 1,8-naphthyridine compound of the formula ##STR9## wherein R is vinyl or 2-fluoroethyl, R.sub.1 and R.sub.2 are the same or different and each ...
|
|
|
Vasodialators 
