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Home Vasodialators Antipsychotic-3-piperidinyl-and-3-pyrrolidinyl-1H-indazoles

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 Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles

Details
Inventors: Strupczewski, Joseph T.;
Assignee: Hoechst-Roussel Pharmaceuticals Inc. (Somerville, NJ)
Primary Examiner: Schwartz; Richard A.
Assistant Examiner:
Attorney, Agent or Firm: Rosenstock; Jerome

Novel 3-(piperidinyl- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for treating psychoses, treating depression, alleviating pain, treating convulsions and treating hypertension utilizing compounds or compositions thereof are disclosed.

DETAILED DESCRIPTION I claim: 1.
A compound of the formula ##STR84## wherein R is hydrogen, loweralkyl, loweralkenyl, lowercycloalkylloweralkyl, ##STR85## cyano, cyanomethyl, formyl, loweralkanoyl, diloweralkylphosphinomethyl, ##STR86## R.
sup.
1 is hydrogen, loweralkyl, loweralkenyl, lowercycloalkylloweralkyl ##STR87## diloweralkylaminloweralkyl, cyano, cyanomethyl, formyl, loweralkanoyl, hydroxymethyl, hydroxyloweralkyl, lowercycloalkylloweralkanoyl, loweralkoxycarbonylloweralkyl, ##STR88## R.
sup.
2 and R.
sup.
2' are independently loweralkyl, 2,2,2-trichloroethyl, phenyl or ##STR89## X, X' and X" are independently hydrogen, halogen, loweralkyl, loweralkoxy, loweralkanoyl, loweralkylthio, cyano, carbamoyl, hydroxy, nitro, amino or trifluoromethyl; Y is oxygen or sulfur; m is 2 or 3, n is 1 or 2, and the sum of m and n is 3 or 4; p, p' and p" are independently 1 or 2 except when X" is halogen p" is 1 through 5; q and q' are independently 1, 2, 3 or 4; R.
sup.
6 is loweralkyl, ##STR90## cycloalkylloweralkyl wherein the cycloalkyl group contains 3 to 10 carbons, a lower alkyl substituted with an amino, loweralkylamino, diloweralkylamino; R.
sup.
7, R.
sup.
8 and R.
sup.
9 are independently hydrogen, loweralkyl or ##STR91## the optical antipode thereof; or the pharmaceutically acceptable salt thereof.
2.
A compound according to claim 1 wherein R is hydrogen or loweralkyl or ##STR92## m and n are each 2; and R.
sup.
1 is hydrogen, loweralkyl, lowercycloalkylloweralkyl, loweralkanoyl, hydroxymethyl, hydroxyloweralkyl, ##STR93## 3.
The compound of claim 2 which is 1-ethyl-3-(1-methyl-4-piperidinyl)-1H-indazole.
4.
The compound of claim 2 which is 6-fluoro-3-(4-piperidinyl)-1H-indazole.
5.
The compound of claim 2 which is 1-(4-chlorophenyl)-3-(1-methyl-4-piperidinyl)-1H-indazole.
6.
The compound of claim 2 which is 6-fluoro-3-[1-(propyl)-4-piperidinyl]-1H-indazole.
7.
The compound of claim 2 which is 1-(3-chlorobenzoyl)-3-(1-methyl-4-piperidinyl)-1H-indazole.
8.
The compound of claim 2 which is 6-fluoro-3-(1-methyl-4-piperidinyl)-1H-indazole



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