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Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations
| Details |
Inventors: Shroot, Braham; Eustache, Jacques; Bernardon, Jean-Michel;
Assignee: Centre International de Recherches Dermatogologiques (C.I.R.D.) (Valbonne, FR)
Primary Examiner: Waddell; Frederick E.
Assistant Examiner: Weddington; K. E.
Attorney, Agent or Firm: Cushman, Darby & Cushman
An aromatic benzamido compound having the formula ##STR1## wherein R.sub.1 represents --CH.sub.2 OH, --CHOHCH.sub.3 or --COR.sub.5, R.sub.5 represents hydrogen, lower alkyl, --OR.sub.6 or ##STR2## R.sub.6 represents hydrogen, lower alkyl or mono- or polyhydroxyalkyl, r' and r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar or taken together form a heterocycle, R.sub.2 represents an .alpha.,.alpha.'-disubstituted alkyl having 4-12 carbon atoms or mono or polycyclic cycloalkyl having 5-12 carbon atoms, the linking carbon of which is quaternary, R.sub.3 represents hydrogen or alkyl having 1-10 carbon atoms, and R.sub.4 represents hydrogen, lower alkyl or hydroxy, and the salts of this aromatic benzamido compound when R.sub.6 represents hydrogen. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A pharmaceutical composition comprising in a vehicle suitable for enteral, parenteral, topical or ocular administration, at least one aromatic benzamido compound having the formula ##STR7## wherein R.
sub.
1 represents --CH.
sub.
2 OH, --CHOHCH.
sub.
3 or --COR.
sub.
5, R.
sub.
5 represents hydrogen, lower alkyl, OR.
sub.
6 or ##STR8## R.
sub.
6 represents hydrogen, lower alkyl or mono- or polyhydroxyalkyl, r' and r" represent hydrogen, lower alkyl, mono- or polyhydroxy alkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar or when taken together form a heterocycle, R.
sub.
2 represents an .
alpha.
,.
alpha.
'-disubstituted alkyl radical having 4-12 carbon atoms or mono or polycyclic cycloalkyl having 5-12 carbon atoms wherein the linking carbon is quaternary, R.
sub.
3 represents hydrogen or alkyl having 1-10 carbon atoms, and R.
sub.
4 represents hydrogen, lower alkyl or hydroxy, and the salts of said aromatic benzamido compound of Formula I when R.
sub.
6 represents hydrogen.
2.
The composition of claim 1 wherein said vehicle is suitable for topical application, said composition containing from 0.
0001 to about 5 percent by weight of said compound based on the total weight of said composition.
3.
A cosmetic composition for body and hair hygiene comprising in a cosmetically acceptable vehicle at least one aromatic benzamido compound having the formula ##STR9## wherein R.
sub.
1 represents --CH.
sub.
2 OH, --CHOHCH.
sub.
3 or --COR.
sub.
5, R.
sub.
5 represents hydrogen, lower alkyl, OR.
sub.
6 or ##STR10## R.
sub.
6 represents hydrogen, lower alkyl or mono- or polyhydroxyalkyl, r' and r" represent hydrogen, lower alkyl, mono- or polyhydroxy alkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar or when taken together form a heterocycle, R.
sub.
2 represents an .
alpha.
,.
alpha.
'-disubstituted alkyl radical having 4-12 carbon atoms or mono or polycyclic cycloalkyl having 5-12 carbon atoms wherein the linking carbon is quaternary, R
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