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Bactericidal formulations for use in veterinary medicine
| Details |
Inventors: Metzger, Karl G.; Zeiler, Hans-Joachim; Scheer, Martin; Voege, Herbert; Grohe, Klaus;
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Primary Examiner: Waddell; Frederick E.
Assistant Examiner: Jordan; Kimberly R.
Attorney, Agent or Firm: Sprung, Horn Kramer & Woods
A method of treating livestock infected with, or protecting livestock against infection from, bacteria which comprises administering to such livestock an antibacterially effective amount of a quinolonecarboxylic acid or derivative of the formula ##STR1## in which A represents nitrogen or .dbd.C--R.sup.4, R.sup.4 represents hydrogen, fluorine, chlorine, nitro or methyl, B represents ##STR2## and B also represents ##STR3## when R.sup.1 does not denote cyclopropyl, and R.sup.5 represents hydrogen, a branched or unbranched alkyl group which has 1 to 4 carbon atoms and which can optionally be substituted by a hydroxyl or methoxy group, R.sup.6 represents hydrogen, methyl or phenyl, R.sup.7 represents hydrogen or methyl, R.sup.8 represents amino, alkyl- or dialkylamino having 1 or 2 carbon atoms in the alkyl group, aminomethyl, alkyl- or dialkylaminomethyl having 1 or 2 carbon atoms in the alkyl group, R.sup.1 represents an alkyl radical having 1 to 3 carbon atoms, cyclopropyl, 2-fluoroethyl vinyl, methoxy, 4-fluorophenyl or methylamino, R.sup.2 represents hydrogen, alkyl having 1 to 6 carbon atoms, and cyclohexyl, benzyl, 2-oxopropyl, phenacyl and ethoxycarbonylmethyl, R.sup.3 represents hydrogen, methyl or ethyl, Z represents oxygen, nitrogen which is substituted by methyl or phenyl, and .dbd.CH.sub.2 --, or a pharmaceutically utilizable salt thereof. |
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DETAILED DESCRIPTION We claim: 1.
A method of treating mycoplasmotic and bacterial infections in fowl which comprises administering drinking water to said fowl, said drinking water containing an antimycoplasmotically or antibacterially effective amount of a quinolonecarboxylic acid and/or derivative of a compound of the formula ##STR11## in which R.
sup.
2 represents hydrogen or C.
sub.
1-4 -alkyl and R.
sup.
5 represents hydrogen, methyl or ethyl.
2.
A method according to claim 1, wherein 10 to 500 mg/l of the compound is added to said drinking water for 1 to 20 days.
3.
A method according to claim 2, wherein 2.
5 to 100 mg/l of the compound is added to said drinking water.
4.
A method according to claim 2, wherein said compound is added to said drinking water for 3 to 10 days.
5.
A method according to claim 1, wherein said fowl are hens.
6.
A method according to claim 1, wherein said compound is 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7 (4-ethyl-1-piperazinyl) quinoline-3-carboxylic acid.
Description:
The present invention relates to bactericidal formulations which contain quinolonecarboxylic acids and their derivatives, for use in the area of veterinary medicine.
It has already been disclosed that quinolonecarboxylic acids and their derivatives have bactericidal properties (U.
S.
Ser.
No.
614,923, filed May 29, 1984, now pending, corresponding to DE OS 3,033,157).
However, nothing has been disclosed about their wide and universal applicability for livestock or about formulations which are especially suitable for applicability for livestock.
In animal medicine the treatment of infections caused by Escherichia coli, salmonellae or mycoplasmas present particular problems, especially when these causative organisms have meanwhile become resistant to known agents.
Bactericidal formulations for use in the area of veterinary medicine have been found, which formulations contain quinolonecarboxylic acids and their derivatives of the formulae I and Ia ##STR4## in which A represents nitrogen or
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Vasodialators 
