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Vasodialators

Certain-lower-alkyl-amino-2-hydroxy-propoxy-pyridines

Naphtholactam dyestuffs

We claim: 1. Naphtholactam dyestuff of the formula ##STR126## wherein Y.sup.1 is hydrogen, C.sub.1 -...

Organic diamine therapeutic compositions and methods

OF THE INVENTION In accordance with one process employed for preparing the organic diamine ...

(Nitrofuryl)pyrazoles, their synthesis and use, and compositions containing them

What is claimed is: 1. An antimicrobially-active pyrazole, the pyrazole ring of which is ...

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OF THE INVENTION N-aminoacid derivatives of dopamine have found a variety of uses in the field of ...

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Enlarged-hetero-ring prostacyclin analogs

I claim: 1. A 4Z compound of formula ##STR110## wherein L is --(CH.sub.2).sub.d --C (R.sub.2).sub.2 ...

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What is claimed is: 1. An improved method for epoxidizing ethylene to ethylene oxide in the vapor ...

Therapeutically active phenoxyalkylamines

We claim: 1. Compounds of the formula I: ##STR6## wherein R.sub.1 represents a cyano group; R.sub.2 ...

Method of protecting plants from pathogens with cyanomethyl aryl sulfonates

We claim: 1. A method of inhibiting fungi or bacteria pathogenic to plants which comprises applying ...

Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

Details

Inventors: Baldwin, John J.;
Assignee: Merck & Co., Inc. (Rahway, NJ)
Primary Examiner: Rotman; Alan L.
Assistant Examiner:
Attorney, Agent or Firm: Szura; Daniel T., Anderson, Jr.; Rudolph J.

Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts and their preparation are disclosed. These pyridines have pharmaceutical properties such as anti-hypertensive activity of rapid onset.

DETAILED DESCRIPTION What is claimed is: 1.
Compound having the formula ##STR15## wherein R is C.
sub.
3 -C.
sub.
4 branched alkyl and R.
sub.
2 is selected from trihalomethyl, ##STR16## pharmaceutically acceptable salt thereof.
2.
Compound of claim 1 wherein R is tert.
butyl.
3.
Compound of claim 1 having the formula ##STR17## 4.
Compound of claim 3 wherein R.
sub.
2 is in the 2-position.
5.
Compound of claim 3 wherein R is tert.
butyl.
6.
Compound of claim 1 having the formula ##STR18## 7.
Compound of claim 6 wherein R is tert.
butyl.
8.
Compound of claim 6 wherein R.
sub.
2 is in the 3, 4 or 6 position.
9.
Compound of claim 6 wherein R.
sub.
2 is in the 3 or 4 position.
10.
Compound of claim 6 having the formula ##STR19## 11.
The compound of claim 10 wherein R is tert.
butyl.
12.
The compound of claim 10 wherein R.
sub.
2 is selected from --CF.
sub.
3, ##STR20## 13.
The compound of claim 12 wherein R.
sub.
1 is hydrogen and R is tert.
butyl.
14.
The compound of claim 13 wherein R.
sub.
2 is --CF.
sub.
3.
15.
The compound of claim 13 wherein R.
sub.
2 is ##STR21## 16.
The compound of claim 13 wherein R.
sub.
2 is ##STR22## 17.
The compound of claim 13 wherein R.
sub.
2 is ##STR23## 18.
The compound of claim 1 having the S-isomer configuration.
19.
The compound of claim 1 having the R-isomer configuration.
20.
Compound having the formula ##STR24## wherein R and R.
sub.
2 are defined as in claim 1 and pharmaceutically acceptable salt thereof.
21.
A method of treating hypertension in hypertensive humans which comprises oral, inhalation, suppository or parenteral administration of an effective amount of a compound of claim 1.
22.
A pharmaceutical composition for treating hypertension comprising a therapeutically effective amount of a compound of claim 1 and pharmaceutically suitable compounding ingredient.
23.
The compound of claim 14 having the S-isomer configuration.
24.
The compound of claim 15 having the S-isomer configuration.
25.
The compound of claim 16 having the S-isomer configuration.
26.
The compound of claim 17 having the S-isomer configuration

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