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Cryoprotective reagents in freeze-drying membranes
| Details |
Inventors: Baldeschwieler, John D.; Goodrich, Jr., Raymond P.;
Assignee: California Institute of Technology (Pasadena, CA)
Primary Examiner: Thexton; Matthew A.
Assistant Examiner: Covert; John M.
Attorney, Agent or Firm: Ashen Golant Martin & Seldon
The ability of phosphoglyceride-containing membranes to withstand the disruptive effects of freezing, thawing, or freeze-drying is enhanced when treated with (a) a compound of the formula R-X-R.sub.1, wherein R is a lipid or lipophilic anchor, X is a hydrophilic linker group, and R.sub.1 is a polyalcohol or carbohydrate group, and (b) ascorbic acid. |
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DETAILED DESCRIPTION What is claimed is: 1.
A composition for the protection of phosphoglyceride-containing biological or synthetic membranes from the disruptive effects of freezing, thawing, or freeze-drying, comprising (a) a compound of the formula R--X--R.
sub.
1 wherein R is a lipid or lipophilic anchor which is suitable for intercalation into and incorporation within a phosphoglyceride layer, X is a hydrophilic linker group, and R.
sub.
1 is a polyalcohol or carbohydrate group, and (b) ascorbic acid.
2.
The composition of claim 1 wherein said anchor is a lipid.
3.
The composition of claim 1 wherein said anchor is a steroid.
4.
The composition of claim 1 wherein R.
sub.
1 is a carbohydrate group.
5.
The composition of claim 4 wherein R.
sub.
1 is a disaccharide.
6.
The composition of claim 1 wherein said ascorbic acid is in the form of sodium ascorbate.
7.
A method for the protection of phosphoglyceride-containing biological or synthetic membranes from the disruptive effects of freezing, thawing, or freeze-drying comprising applying to an aqueous solution of said membranes (a) from about 10 to about 40 mole% of a compound of the formula R--X--R.
sub.
1 wherein R is a lipid or lipophilic anchor which is suitable for intercalation into and incorporation within a phosphoglyceride layer, X is a hydrophilic linker group, and R.
sub.
1 is a polyalcohol or carbohydrate group, and (b) ascorbic acid.
8.
The method of claim 7 wherein the concentration of said sodium ascorbate to said aqueous solution ranges from about 25 to about 500 mM.
9.
The method of claim 8 wherein the concentration of said sodium ascorbate to said aqueous solution ranges from about 40 to about 100 mM.
10.
The method of claim 7 wherein the anchor is a lipid.
11.
The method of claim 7 wherein the anchor is a steroid.
12.
The method of claim 7 wherein R.
sub.
1 is a carbohydrate group.
13.
the method of claim 12 wherein R.
sub.
1 is a disaccharide.
14.
The method of claim 7 wherein said ascorbic acid is in the form of sodium ascorbate.
Description:
RELATED APPLICATION The present invention is an improvement over the invention disclosed and claimed in our copending application Ser
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Vasodialators 
