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Decreasing the toxicity of an ibuprofen salt
| Details |
Inventors: Smith, Walton J.;
Assignee:
Primary Examiner: Friedman; Stanley J.
Assistant Examiner:
Attorney, Agent or Firm: Larson and Taylor
The toxicity of salts of ibuprofen is decreased. |
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DETAILED DESCRIPTION I claim: 1.
A method of decreasing the toxicity of a salt of ibuprofen by combining the salt with from one to five molar excess of a bicarbonate or carbonate.
2.
claim 1 in which the molar excess of bicarbonate is 1.
5 to 2 moles per mole of the ibuprofen salt.
3.
A pharmaceutically acceptable composition comprising a salt of ibuprofen combined with from one to five molar excess of a bicarbonate or carbonate.
Description:
This invention relates to improved carboxylic acid compositions and their use.
More particularly it is concerned with compositions of carboxylic acids which have some useful biological activity and yet display some toxic effects.
It is an object of the present invention to provide a pharmaceutically acceptable composition comprising a biologically active carboxylic acid compound or its salt and a detoxifier for that compound.
This invention is an outgrowth of two discoveries which I have made relating to biologically active carboxylic acids.
The first discovery is that the inherent toxicity of this wide group of compounds is due to the neutralized acid.
Previously it had been thought that much or most of the activity of this group of compounds was due to the acid moiety in unneutralized form.
Thus, I have discovered that much or most of the biological activity of these compounds is present when neutralized and in salt form.
My second discovery in this connection was that much of the biological activity of salts of carboxylic acids could be non-effective or neutralizd by bicarbonate ions without altering the pH of the carboxylic acid salt.
I have taken advantage of these two major discoveries in developing methods of detoxifying carboxylic acid salts which is the subject of this invention.
So that this invention be better understood, I shall enlarge on these discoveries and further describe this invention.
I have used a variety of test methods to confirm the benefits of this invention.
This includes animal studies, however, the basic discovery was made with plants
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