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Home Vasodialators Derivatives-of-1-2-3-or-4-quinolyl-2-or-3-2-or-3-piperidyl-or-pyrrolidinyl-ethanone-or-propanone-and-their-utilization-as-antiarrhythmics-anticonvulsivants-and-for-the-treatment-of-anxiety

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 Derivatives of 1-(2-,3- or 4-quinolyl)-2- or -3-(2- or 3-piperidyl or -pyrrolidinyl) ethanone or propanone, and their utilization as antiarrhythmics, anticonvulsivants and for the treatment of anxiety

Details
Inventors: Dubroeucq, Marie-Christine; Gueremy, Claude G. A.; Le Fur, Gerard R.; Mizoule, Jacques;
Assignee: Pharmindustrie (Gennevilliers, FR)
Primary Examiner: Daus; Donald G.
Assistant Examiner: Rivers; Diana G.
Attorney, Agent or Firm: Beveridge, DeGrandi and Kline

Compounds, useful as medicaments, of the formula: ##STR1## in which R is fixed in position 2 or 4 on the cycle of the quinoline and indicates a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, pyridyl, thienyl, phenyl or substituted phenyl group, X is fixed in position 5, 6, 7 or 8 on the cycle of the quinoline and indicates a hydrogen or halogen atom or an alkyl, alkoxy or alkylthio group containing 1 to 4 carbon atoms or CF.sub.3 group, R.sub.1 is a hydrogen atom or an alkyl containing 1 to 4 carbon atoms, alkenyl containing 3 to 4 carbon atoms or arylalkyl group, A is a CO, CHOH, or CH.sub.2 group, n and p are equal to 1 or 2, the group ##STR2## is fixed in position 2, 3 or 4 on the cycle of the quinoline and the group ##STR3## is fixed in position 2 or 3 on the nitrogen heterocycle ##STR4##

DETAILED DESCRIPTION What is claimed is: 1.
Compounds of the formula: ##STR30## in which R is fixed in position 2 or 4 on the cycle of the quinoline and represents a phenyl, pyridyl or thienyl group, or a phenyl group substituted by one or two substituents selected from the halogen atoms, the alkyl, alkoxy and alkylthio groups having 1 to 4 carbon atoms and the trifluoromethyl group, X is fixed in position 5, 6, 7 or 8 on the cycle of the quinoline and represents a hydrogen or halogen atom, an alkyl, alkoxy or alkylthio group having 1 to 4 carbon atoms or the trifluoromethyl group, R.
sub.
1 represents a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms, an alkenyl group containing 3 or 4 carbon atoms or an arylalkyl group of which the alkyl part contains 1 to 3 carbon atoms, A represents a CO, CHOH or CH.
sub.
2 group, n is a whole number equal to 1 or 2, p is a whole number equal to 1 or 2, the group: ##STR31## is fixed in position 4 or 2 on the cycle of the quinoline, and the group ##STR32## is fixed in position 2 or 3 on the nitrogen heterocycle: ##STR33## their diastereoisomers, racemic and enantiomers, and their salts of addition with mineral or organic acids.
2.
Compounds according to claim 1 in which X is a hydrogen atom, R is a phenyl group and n is equal to 1.
3.
Compound according to claim 2 of the formula: ##STR34## and its salts of addition with the mineral or organic acids.
4.
A medicament, useful as an antiarrhythmic, hypnotic, anticonvulsivant and for the treatment of states of anxiety and various psychoneurotic states, which contains a pharmaceutically acceptable carrier and, as the active principle, 1 to 50 mg per unit dose of a compound corresponding to formula (I) of claim 1 or a salt of such a compound with a pharmaceutically acceptable acid.
5.
Medicament according to claim 4 which contains as active principle, 1 to 50 mg per unit dose of the compound of the formula: ##STR35## or a salt of this compound with a pharmaceutically acceptable acid.
6.
A process for treating a human suffering from anxiety, which comprises orally administering to said human 5 to 250 mg per day of a compound corresponding to formula (I) of claim 1 or a salt thereof with a pharmaceutically acceptable acid



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