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Dermal pharmaceutical preparations
| Details |
Inventors: Hosaka, Yoshifumi; Otsuka, Saburo; Kinoshita, Takashi; Ito, Yusuke;
Assignee: Nitto Electric Industrial Co., Ltd. (Osaka, JP)
Primary Examiner: Robinson; Ellis P.
Assistant Examiner: Horne; Leon R.
Attorney, Agent or Firm: Sughrue, Mion, Zinn, Macpeak & Seas
A dermal pharmaceutical preparation comprising a soft support having provided thereon a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and a drug, wherein said pressure-sensitive adhesive is a copolymer comprising a (meth)acrylamide having an amino group as a comonomer unit. The preparation remains the drug in a dissolved state and is excellent in drug liberation and adhesion to the skin. |
|
DETAILED DESCRIPTION OF THE INVENTION The support which can be used in the present invention functions to retain a layer of a pressure-sensitive adhesive containing a drug and is selected from materials having moderate softness so as to follow the movement of the skin when applied thereto and not to cause uncomfortableness when applied to the part subject to bending.
Examples of the support meeting these requirements include films or sheets of plastics, e.
g.
, polyolefins (e.
g.
, polyethylene), polyester, polyvinyl chloride, polyvinylidene chloride, polyamide, ethylene-vinyl acetate copolymers, polyurethane, etc.
, rubber and/or synthetic resin foamed sheets or films, nonwoven cloth, woven cloth, paper, metal foils, and various laminates of these materials.
The thickness of the support is not particularly limited and is appropriately determined according to the material of the support.
However, the thickness of the support is generally 2 to 2,000 .
mu.
m and preferably 5 to 500 .
mu.
m.
If the thickness thereof is too small, it is difficult to obtain a sufficient strength and also it is difficult to handle the same due to the lack of self-supporting property.
On the other hand, if the thickness thereof is too large, there is uncomfortable feeling when the pharmaceutical preparation is adhered on a skin.
The pressure-sensitive adhesive into which a drug is incorporated should exhibit adhesiveness to the skin for a prolonged period of time.
The pressure-sensitive adhesive to be used in the present invention is characterized by containing a (meth)acrylamide having an amino group as a comonomer unit.
From the viewpoint of adhesion to the skin, internal cohesiveness, stability of the drug to decomposition, and retention of the drug, the acrylic pressure-sensitive adhesive to be used preferably contains at least 50% by weight of an alkyl (meth)acrylate having from 4 to 12 carbon atoms in the alkyl moiety thereof as a main comonomer.
Other examples of the main comonomer are vinyl ether and the like, but alkyl (meth)acrylate is preferred
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Vasodialators 
