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Device comprising liner for protecting fluid sensitive medicament
| Details |
Inventors: Eckenhoff, James B.; Magruder, Judy A.; Cortese, Richard; Peery, John R.; Wright, Jeremy C.;
Assignee: ALZA Corporation (Palo Alto, CA)
Primary Examiner: Cashion, Jr.; Merrell C.
Assistant Examiner: Horne; Leon R.
Attorney, Agent or Firm: Sabatine; Paul L., Mandell; Edward L., Stone; Steven F.
A delivery device is disclosed for delivering a beneficial agent to an animal. The device comprises a wall housing an internal space, a beneficial agent in the space, expandable means in the space for causing the beneficial agent to be delivered from the device and means in the space for shielding the beneficial agent from fluid. |
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DETAILED DESCRIPTION OF THE DRAWING FIGURES Turning now to the drawings in detail, which are examples of various delivery devices provided by the invention and which examples are not to be construed as limiting, one example of a delivery device is seen in FIG.
1a and in FIG.
1b as indicated by the number 10.
In FIG.
1a, delivery device 10 comprises body 11 formed of wall 12, which wall 12 surrounds and defines an internal lumen, not seen in FIG.
1a.
Therapeutic delivery device 10 comprises at least one passageway 13, indicated by a partial hole, for delivering a beneficial agent formulation from delivery device 10.
In FIG.
1b, delivery device 10 comprises a body 11 comprising wall 12, which wall surrounds and forms an internal lumen, not seen in FIG.
1b.
Delivery device 10 comprises at least one passageway 13 for delivering a beneficial agent formulation from delivery device 10.
In FIG.
1b, delivery device 10 comprises a dome-shaped end 8 similar to lead end 9 for aiding in placing delivery device 10 in an animal host.
In an embodiment not seen, device 10 can be manufactured with a pan of flat ends 8 and 9.
FIG.
2a and FIG.
2b depict an opened view of delivery device 10 of FIG.
1a and FIG.
1b through 2--2 of device 10.
Therapeutic delivery device 10 of FIG.
2a comprises body 11, wall 12, lead end 9, trailing end 8 and passageway 13.
Wall 12 surrounds and defines an internal lumen 14, also defined as internal compartment 14.
In a presently preferred embodiment wall 12 is formed at least in part of a semipermeable wall forming composition that is permeable to the passage of fluid and it is substantially impermeable to the passage of a beneficial agent and other ingredients contained in delivery device 10.
Wall 12 optionally comprises additional wall forming compositions such as a polymeric means for increasing or for decreasing the permeability of wall 12 to the passage of fluid, and a plasticizer that imparts flexibility and workability to wall 12.
Wall 12 is non-toxic and it maintains its physical and chemical integrity, that is, wall 12 doesn't erode during the dispensing period
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Vasodialators 
