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Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
| Details |
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Inventors: Strupczewski, Joseph T.; Helsley, Grover C.; Chiang, Yulin; Bordeau, Kenneth J.; Glamkowski, Edward J.;
Assignee: Hoechst-Roussel Pharmaceuticals, Inc. (Somerville, NJ)
Primary Examiner: Tsang; Cecilia
Assistant Examiner:
Attorney, Agent or Firm: Finnegan, Henderson, Farabow, Garrett & Dunner
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal. |
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DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The compounds of this invention are useful as antipsychotic drugs and as analgesic agents.
The compounds of the invention can contain a variety of different substituents and chemical groups.
As used herein, when the term "lower" is mentioned in connection with the description of a particular group, the term means that the group it is describing contains from 1 to 6 carbon atoms.
The term "alkyl" as used herein refers to a straight or branched chain hydrocarbon group containing no unsaturation, for example, methyl, ethyl, isopropyl, 2-butyl, neopentyl, or n-hexyl.
The term "alkoxy" as used herein refers to a monovalent substituent comprising an alkyl group linked through an ether oxygen having its free valence bond from the ether oxygen, e.
g.
methoxy, ethoxy, propoxy, butoxy, or pentoxy.
The term "alkylene" as used herein refers to a bivalent radical of a lower branched or unbranched alkyl group having valence bonds on two terminal carbons thereof, for example, ethylene (--CH.
sub.
2 CH.
sub.
2 --), propylene (--CH.
sub.
2 CH.
sub.
2 CH.
sub.
2 --), or isopropylene ##STR65## The term "cycloalkyl" refers to a saturated hydrocarbon group possessing at least one carbocyclic ring, the ring containing from 3 to 10 carbon atoms such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclodecyl and the like.
The term "alkanoyl" refers to the radical formed by removal of the hydroxyl function from an alkanoic acid.
More particularly, the term "alkanoyl" as used herein refers to an alkyl carbonyl moiety containing from 2 to 11 carbon atoms, e.
g.
##STR66## Examples of alkanoyl groups are formyl, acetyl, propionyl, 2,2-dimethylacetyl, hexanoyl, octanoyl, decanoyl, and the like.
The term "alkanoic acid" refers to a compound formed by combination of a carboxyl group with a hydrogen atom or alkyl group.
Examples of alkanoic acids are formic acid, acetic acid, propanoic acid, 2,2-dimethylacetic acid, hexanoic acid, octanoic acid, decanoic acid, and the like
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Vasodialators 
