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Isoquinolium compounds for treating diabetes
| Details |
Inventors: Garside, Peter; Dimsdale, Michael John;
Assignee: Allen & Hanburys Limited (London, EN)
Primary Examiner: Waddell; Frederick E.
Assistant Examiner:
Attorney, Agent or Firm: Bacon & Thomas
Compounds of the general formula 1; ##STR1## in which R.sup.1 and R.sup.5 which may be the same or different represent an alkyl, alkenyl or alkynyl group, which groups may optionally be substituted by an amino, alkylamino or dialkylamino groups, or by hydroxy, alkoxy (C.sub.1-4), aroyl, aryl or aryloxy groups, in which the aroyl, aryl or aryloxy groups may contain an alkoxy (C.sub.1-4) substituent; and R.sup.5 may in addition represent a cycloalkyl group containing from 4 to 8 carbon atoms or a heterocyclic group; R.sup.2 and R.sup.3 which may be the same or different represent a hydrogen atom or an alkyl group; R.sup.4 represents a hydrogen atom or an alkyl group which alkyl group may be substituted by an aryl or aryloxy group which aryl group or aryloxy group may be substituted by an alkoxy (C.sub.1-4) substituent, or R.sup.4 may represent an aryl group which may be substituted by an alkoxy (C.sub.1-4) substituent; and X represents a pharmaceutically acceptable anion of an inorganic or organic acid. These compounds have therapeutic utility particularly improving glucose utilization. |
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DETAILED DESCRIPTION We claim: 1.
A method of treatment of diabetes which comprises administering to a patient an effective amount of a compound of the formula: ##STR6## in which R.
sup.
1 represents C.
sub.
1-4 alkyl; aminoethyl; dimethylaminoethyl; 2-ethoxyethyl; allyl; propynyl; benzyl, p-methoxybenzyl; phenoxyethyl; phenacyl or 4-methoxyphenacyl; R.
sup.
2 represents hydrogen or C.
sub.
1-4 alkyl; R.
sup.
3 represents hydrogen; R.
sup.
4 represents hydrogen; methyl, ethyl; benzyl; or p-methoxyphenyl; R.
sup.
5 represents C.
sub.
1-5 alkyl; 2-aminoethyl; 2-hydroxyethyl; 2-ethoxyethyl, 2-methoxyethyl, 3-methoxypropyl, ethoxymethyl; allyl, dimethylallyl; cyclopentyl; benzyl; phenoxyethyl or 3-tetrahydrofuranyl; X represents iodide, bromide, chloride, toluene sulphonate or hydrogen sulphate.
2.
The method of claim 1 wherein R.
sup.
1 represents methyl, ethyl, isopropyl or butyl; and R.
sup.
5 represents methyl, ethyl, isopropyl, pentyl or isopentyl.
3.
The method of claim 1 wherein the compound is 6-(2-ethoxyethoxy)-2-methylisoquinolinium bromide monohydrate.
4.
A method of treatment of diabetes which comprises administering to a patient an effective amount of 6-ethoxy-2-(2-hydroxyethyl)isoquinolinium bromide.
5.
The method of claim 1 wherein the compound is administered orally.
6.
The method of claim 5 wherein the effective amount of the compound is in a dosage range of from 5-500 mg daily.
7.
The method of claim 1 wherein the compound is 6-methoxy-2-methylisoquinolinium iodide.
8.
The method of claim 1 wherein the compound is 6-methoxy-2,3-dimethylisoquinolinium iodide.
9.
The method of claim 1 wherein the compound is 6-methoxy-1,2-dimethylisoquinolinium iodide.
10.
The method of claim 1 wherein the compound is 6-ethoxy-2-butylisoquinolinium iodide.
11.
The method of claim 1 wherein the compound is 6-ethoxy-2-ethylisoquinolinium hydrogen sulphate, monohydrate.
12.
The method of claim 1 wherein the compound is 6-ethoxy-2-methylisoquinolinium bromide monohydrate.
13.
The method of claim 1 wherein the compound is 6-ethoxy-2,3-dimethylisoquinolinium bromide monohydrate
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Vasodialators 
