Lipogenesis inhibition by certain esters of substituted benzodioxincarboxylic acids

DETAILED DESCRIPTION I claim as my invention: 1.
A method of inhibiting lipogenesis in a mammal, which comprises administering, to a mammal in need of such treatment, orally or parenterally a lipogenesis inhibiting amount of a compound of the formula ##STR2## wherein "alkyl" is alkyl of from one to four carbon atoms, and the substituent moiety or moieties, R, are as follows, the number(s) preceding the moieties indicating the position of each of said moieties on the ring:
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Species No.

(R).
sub.
n
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1 H (n = zero)
2 mixture of the 6- and 7-methyl isomers (n = 1)
3 mixture of the 6- and 7-fluoro isomers (n = 1)
4 mixture of the 6- and 7-bromo isomers (n = 1)
5 mixture of the 5- and 8-methoxy isomers (n = 1)
6 6,7-dimethyl (n = 2)
7 6-phenyl (n = 1)
8 7-phenyl (n = 1)
9 7-(hydroxyethyl) (n = 1)
10 mixture of the 6- and 7-methoxy isomers (n = 1).

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Description



Description:
DESCRIPTION OF THE INVENTION It has been found that lipogenesis in mammals is inhibited by alkyl esters of certain substituted 2,3-dihydro-benzodioxin-2-carboxylic acids, of the formula ##STR1## wherein "alkyl" is straight-chain or branched-chain alkyl of from one to four carbon atoms, and the substituent moiety or moieties, R, are as follows, the number(s) preceding the moieties indicating the position of each of said moieties on the ring:
______________________________________
Species
No.
(R).
sub.
n
______________________________________
1 H (n = zero)
2 mixture of the 6- and 7-methyl isomers (n = 1)
3 mixture of the 6- and 7-fluoro isomers (n = 1)
4 mixture of the 6- and 7-bromo isomers (n = 1)
5 mixture of the 5- and 8-methoxy isomers (n = 1)
6 6,7-dimethyl (n = 2)
7 6-phenyl (n = 1)
8 7-phenyl (n = 1)
9 7-(hydroxyethyl) (n = 1)
10 mixture of the 6- and 7-methoxy isomers (n = 1)