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Methods for treating dermatitis using descarboethoxyloratadine
| Details |
Inventors: Handley, Dean A.; Rubin, Paul D.;
Assignee: Sepracor Inc. (Marlborough, MA)
Primary Examiner: Jordan; Kimberly
Assistant Examiner:
Attorney, Agent or Firm: Pennie & Edmonds LLP
The invention relates to methods of utilizing descarboethoxyloratadine ("DCL") for the treatment of dermatitis. The invention also encompasses the topical administration of descarboethoxyloratadine using various dosage forms for the treatment of dermatitis. |
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DETAILED DESCRIPTION OF THE INVENTION The present invention encompasses a method of treating allergic asthma in a human while avoiding the concomitant liability of adverse side-effects associated with the administration of non-sedating antihistamines, comprising administering to a human a composition, said composition comprising (i) a therapeutically effective amount of DCL or a pharmaceutically acceptable salt thereof; (ii) a therapeutically effective amount of a decongestant; and a pharmaceutically acceptable carrier.
DCL and a decongestant may also be administered separately in the method of treating allergic asthma.
For example, DCL and a decongestant may be administered concurrently or sequentially, i.
e.
, DCL and a decongestant may be administered in combination either concurrently or by the sequential administration of DCL and decongestant or the sequential administration of a decongestant and DCL.
Thus, the present invention also encompasses a method of treating allergic asthma in a human while avoiding the concomitant liability of adverse side-effects associated with the administration of non-sedating antihistamines, comprising administering to a human a therapeutically effective amount of DCL and a therapeutically effective amount of a decongestant.
The present invention also relates to a method of treating allergic asthma in a human while avoiding the concomitant liability of adverse side-effects associated with the administration of non-sedating antihistamines, comprising administering to a human a composition, said composition comprising (i) a therapeutically effective amount of DCL or a pharmaceutically acceptable salt thereof; (ii) a therapeutically effective amount of a leukotriene inhibitor selected from the group consisting of 5-lipoxygenase ("5-LO") inhibitors, 5-lipoxygenase activating protein ("FLAP") antagonists, and leukotriene D.
sub.
4 ("LTD.
sub.
4 ") antagonists; and a pharmaceutically acceptable carrier.
The administration of DCL and a leukotriene inhibitor in the methods of the present invention for treating allergic asthma may be either concurrently or sequentially, i
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Vasodialators 
