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Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
| Details |
Inventors: Boschetti, Egisto; Brouard, Michel; Drouet, Ludovic; Girot, Pierre; Laurent, Alexandre; Wassef, Michel;
Assignee: Assistance Publique Hopitaux de Paris (Paris, FR); BioSepra S.A. (Villeneuve-la-Garenne Cedex, FR)
Primary Examiner: Azpuru; Carlos
Assistant Examiner:
Attorney, Agent or Firm: Pennie & Edmonds LLP
The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter. |
|
DETAILED DESCRIPTION What is claimed is: 1.
An injectable solution suitable for the embolization of microspheres, which comprises a microsphere having a diameter ranging between about 10 to about 2000 .
mu.
m wherein said microsphere comprises a copolymer comprising, in copolymerized form, about 25 to about 98% neutral hydrophilic acrylic monomer by weight, about 2 to about 50% difunctional monomer by weight, about 0 to about 50% by weight of one or more monomers having a cationic charge, and about 1 to about 30% by weight of a functionalized monomer making possible the detection of the microsphere, coated with a cell adhesion promoter.
2.
An injectable solution according to claim 1, characterized in that the functionalized monomer comprises a monomer covalently linked to a marking agent selected from the group consisting of dyes, imaging agents and contrasting agents.
3.
An injectable solution according to claim 2, characterized in that the functionalized monomer is selected from the group consisting of N-acryloyl hexamethylene-anthraquinone dyes, N-acryloyl hexamethylene-azoic dyes, (acrylamido-3-propionamido)-3-triiodo-2,4,5-benzoic acid or polymers thereof, and acrylamido-3-triiodo-2,4,6-benzoic polyacid.
4.
An injectable solution according to claim 2, characterized in that the marking agent is directly introduced in powdered form in the initial monomer solution.
5.
An injectable solution for therapeutic embolization, comprising a microsphere, having a diameter ranging between about 10 to about 2000 .
mu.
m, wherein said microsphere comprises a hydrophilic acrylic copolymer coated with a cell adhesion promoter and a marking agent.
6.
A method for the therapeutic embolization of microspheres which comprises administering to a mammal an injectable solution according to claims 1, 2, 3, 4 or 5.
7.
The method according to claim 6, characterized in that the acrylic copolymer comprises, in copolymerized form, about 25 to about 98% neutral hydrophilic acrylic monomer by weight, about 2 to about 50% difunctional monomer by weight, and about 0 to about 50% by weight of one or more monomers carrying a cationic charge
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Vasodialators 
