Nitrosated and nitrosylated .alpha.-adrenergic receptor antagonist compounds, compositions and their uses

DETAILED DESCRIPTION OF THE INVENTION The term "lower alkyl" as used herein refers to branched or straight chain alkyl groups comprising one to ten carbon atoms, including methyl, ethyl, propyl, isopropyl, n-butyl, t-butyl, neopentyl and the like.
The term "alkoxy" as used herein refers to R.
sub.
50 O-wherein R.
sub.
50 is lower alkyl as defined above.
Representative examples of alkoxy groups include methoxy, ethoxy, t-butoxy and the like.
The term "alkoxyalkyl" as used herein refers to an alkoxy group as previously defined appended to an alkyl group as previously defined.
Examples of alkoxyalkyl include, but are not limited to, methoxymethyl, methoxyethyl, isopropoxymethyl and the like.
The term "hydroxy" as used herein refers to --OH.
The term "hydroxyalkyl" as used herein refers to a hydroxy group as previously defined appended to an alkyl group as previously defined.
The term "alkenyl" as used herein refers to a branched or straight chain C.
sub.
2 -C.
sub.
10 hydrocarbon which also comprises one or more carbon-carbon double bonds.
The term "amino" as used herein refers to --NH.
sub.
2.
The term "nitrate" as used herein refers to --O--NO.
sub.
2.
The term "alkylamino" as used herein refers to R.
sub.
11 NH-- wherein R.
sub.
11 is a lower alkyl group, for example, methylamino, ethylamino, butylamino, and the like.
The term "dialkylamino" as used herein refers to R.
sub.
12 R.
sub.
13 N-- wherein R.
sub.
2 and R.
sub.
13 are independently selected from lower alkyl, for example dimethylamino, diethylamino, methyl propylamino and the like.
The term "nitro" as used herein refers to the group --NO.
sub.
2 and "nitrosated" refers to compounds that have been substituted therewith.
The term "nitroso" as used herein refers to the group --NO and "nitrosylated" refers to compounds that have been substituted therewith.
The term "aryl" as used herein refers to a mono- or bicyclic carbocyclic ring system having one or two aromatic rings including, but not limited to, phenyl, naphthyl, tetrahydronaphthyl, indanyl, indenyl, and the like