 Ear canal electrode |
| It is an object of this invention to provide a noninvasive external ear canal electrode with ... |
|
| Method of reducing the level of low density lipoproteins in the serum of a patient |
| What is claimed is: 1. A method for reducing the level of low density lipoproteins in the serum of ... |
|
| 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| What we claim is: 1. A compound of the formula: R.sub.d.sup.1 --A.sup.14 --R.sup.e in which R.sub.d.... |
|
| Synthesis of vincaminic acid derivatives |
| I claim: 1. A process for the preparation of vincaminic acid derivatives of formula ##STR4## in ... |
|
| Certain N-phenyl or N-pyridyl aza sulfonium salts |
| OF THE INVENTION More specifically, this invention provides an improved process for making ... |
|
| Apparatus for treating finely divided materials with gaseous fluid |
| My invention aims to provide a method which does not present the aforementioned disadvantages and ... |
|
| Flavoring compositions containing dialkyl-.alpha.,.beta.-diacyl succinates |
| What is claimed is: 1. A flavor composition comprising a flavor component and 0.0001% to 30% by ... |
|
| Method of forming an image with photographic likeness on chocolate |
| It is an object of the present invention to economically create a quality photographic image with ... |
|
| 6-Acylamino-penam-3-carboxylic and 7-acylamino-3-cephem-4-carboxylic acids |
| We claim: 1. A compound of the formula I ##STR11## wherein the grouping -S-A- represents a radical ... |
|
| Dry pesticidal compositions |
| What is claimed is: 1. A dry pesticidal composition of a toxicant useful for crops having a melting ... |
|
|
Preparation of alkyl adipates
| Details |
Inventors: Jenck, Jean;
Assignee: Rhone-Poulenc Chimie de Base (Courbevoie, FR)
Primary Examiner: Trousof; Natalie
Assistant Examiner: Clarke; Vera C.
Attorney, Agent or Firm: Burns, Doane, Swecker & Mathis
Alkyl adipates are prepared by reacting an alcohol and carbon monoxide with an alkyl pentenoate in the presence of (i) a catalytically effective amount of a cobalt catalyst, (ii) a tertiary nitrogen base, and (iii) hydrogen, with the hydrogen comprising at least 0.1% by volume of the carbon monoxide, and said reaction being carried out in (iv) an aromatic hydrocarbon or substituted aromatic hydrocarbon reaction medium. |
|
DETAILED DESCRIPTION OF THE INVENTION More particularly according to the present invention, an alcohol and carbon monoxide are therefore reacted with an alkyl pentenoate.
Alkyl pentenoates can be obtained by reacting an alcohol and carbon monoxide with butadiene, in a manner which is in itself known.
Alkyl pent-3-enoates are obtained as the principal products.
Within the scope of the present process, it is also possible to use alkyl pent-2-enoates, which are obtained, for example, by isomerization of the corresponding pent-3-enoates, these .
alpha.
,.
beta.
-unsaturated esters proving more reactive.
An alcohol is also used to carry out the present process.
This other starting material can be represented by the formula R'OH, in which R' is an alkyl radical containing at most 12 carbon atoms and optionally substituted by one or two hydroxyl groups, or a cycloalkyl radical having from 5 to 7 carbon atoms, or an aralkyl radical having from 7 to 12 carbon atoms, or a phenyl radical.
Exemplary of alcohols which can be used according to the present invention, representative are methanol, ethanol, isopropanol, n-propanol, tert.
-butanol, n-hexanol, cyclohexanol, 2-ethylhexan-1-ol, dodecan-1-ol, ethylene glycol, hexane-1,6-diol, benzyl alcohol, phenylethyl alcohol and phenol.
It is preferred to use an alkanol having at most 4 carbon atoms; methanol and ethanol are suitable for carrying out the present process.
It is advantageous to use the alcohol corresponding to the alkyl radical of the pentenoate selected as the starting material.
The alcohol and the alkyl pentenoate can be used in stoichiometric amounts.
However, it is preferable to use an excess of alcohol in a proportion of 1 to 10, or even more preferable to use from 2 to 5 mols of alcohol per mol of alkyl pentenoate.
The reaction is carried out in the presence of a metal catalyst selected from among cobalt and compounds thereof.
Any source of cobalt which is capable of reacting with carbon monoxide in the reaction medium to give cobalt carbonyl complexes in situ can be used within the scope of the invention
|
| Related patents |
|
|
Process for oxidation of benzene to phenol precursor
We claim: 1. A process for the catalytic reaction of benzene which comprises contacting benzene with (a) an oxidant selected from H.sub.2 O.sub.2, perfluoroperoxyacetic ...
|
|
|
Novel 5-substituted 1,2,4,-oxadiazole derivatives and preparation thereof
What is claimed is: 1. A compound of the formula ##STR129## wherein R.sub.1 is phenyl or substituted phenyl; R.sub.2 and R.sub.3 are independently hydrogen or halogen; X....
|
|
|
Therapeutic substituted indole compounds and compositions thereof
We claim: 1. A compound of formula (I) ##STR39## wherein R, R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl; R.sup.3 and R.sup.4 are ...
|
|
|
Methods of inhibiting ovarian dysgenesis, delayed puberty, or sexual infantilism
OF THE INVENTION The current invention concerns the discovery that a select group of 2-phenyl-3-aroylbenzothiophenes (benzothiophenes), those of formula I, are useful ...
|
|
|
Phenylvinyl morpholine compounds
What we claim is: 1. A morpholine derivative of the formula: ##STR17## wherein A stands for the trans vinylene radical and X stands for a phenyl radical which is ...
|
|
|
Method of reducing plant growth height using phenylalkylmorpholines
We claim: 1. A method of reducing the growth height in plants, which comprises allowing an effective amount of phenylalkylamine of the formula ##STR12## where the ...
|
|
|
Piperazine compounds
We claim: 1. A compound of formula (I) ##STR16## wherein R.sub.1 represents --COR.sub.4, --CO.sub.2 R.sub.4 or --COCO.sub.2 R.sub.4 (where R.sub.4 represents a hydrogen ...
|
|
|
Insecticidal heterocyclic compounds
What is claimed is: 1. A heterocyclic compound of the formula: ##STR59## wherein A represents 2-chloropyridin-5-yl or 2-chlorothiazol-5-yl; Z.sup.1 represents O; R.sup.2 ...
|
|
|
Self-locking cerebral electrical probe
In view of the foregoing objects, the instant invention contemplates a cerebral probe for stereoelectroencephalographic exploration which comprises a long, hollow, ...
|
|
|
Transvenous cardiovascular integrated lead anchoring sleeve, protector, and permanent lead introducer stop gap
The present invention overcomes the problems inherent in the prior art apparatus and techniques by employing a suturing sleeve which is permanently attached about the ...
|
|
|
Vasodialators 
