Solid oral dosage forms of ifosfamide

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS The invention is illustrated by the following examples: EXAMPLE 1 Ifosfamide capsule mass In accordance with the invention, the capsule mass is for example manufactured according to the following method: For 12,000 capsules of 250 mg each, 3.
0 kg ifosfamide, 1.
002 mg microcrystalline cellulose and 0.
018 kg highly disperse silicon dioxide are, for example, passed through a 0.
8 mm sieve and then mixed in a suitable mixer for 4 minutes.
0.
06 kg of magnesium stearate are then added to this mixture (sieved through a 0.
8 mm sieve) and mixing is repeated for i minute.
The finished capsule mass is then dispensed with a capsule machine fitted with size 1 molds into size 1 hard gelatin capsules so that each capsule contains ca.
340 mg of the capsule mass.
For 20,000 capsules of 500 mg each, 10.
0 kg ifosfamide, 3.
34 kg microcrystalline cellulose and 0.
06 kg highly disperse silicon dioxide are for example passed through a 0.
8 mm sieve and then mixed in a suitable mixer for 4 minutes-0.
2 kg of magnesium stearate are then added to this mixture (sieved through a 0.
8 mm sieve) and mixing repeated for 1 minute.
The finished capsule mass is then filled in a capsule machine fitted with size 00 molds into size 00 hard gelatin capsules so that each capsule contains ca.
680 mg of the capsule mass.
The microcrystalline cellulose is used for example in the form of Avicel PH 105.
Avicel PH 105 has a special grain size spectrum and is a flowing substance with good binding and flowing properties.
To manufacture gastric juice resistant capsules, a coating suspension in organic solvent (ifosfamide) is for example applied to 2500 size 1 capsules containing 250 mg ifosfamide.
The 3000 g of suspension contain: 1440 g anionic polymerizate of methacrylic acid and methacrylic acid esters with a mean molecular weight of for example 150,000, to which a conventional softener has been added, 18 g of 1,2-propandiol, 36 g of magnesium stearate and 1506 g of isopropanol.
The copolymerizate of methacrylic acid and methylmethacrylate that may for example be considered is Eudragit L