Substituted iminodiacids, their preparation and pharmaceutical compositions containing them

DETAILED DESCRIPTION We claim: 1.
A compound selected from the group consisting of iminodiacid compounds having the formula: ##STR20## wherein R.
sub.
1 represents lower-alkyl having 1 to 4 carbon atoms, inclusive, R.
sub.
2 represents hydrogen or lower-alkyl having 1 to 4 carbon atoms, inclusive, R.
sub.
3 is --CH.
sub.
2 CH.
sub.
2 --CH.
sub.
3, in racemic form or as an optical isomer, a salt thereof with a pharmaceutically-acceptable inorganic or organic base, and an addition salt thereof with a pharmaceutically-acceptable inorganic or organic acid.
2.
A compound of claim 1, in which R.
sub.
1 is a methyl radical.
3.
(2S)-1-{N[(1RS)-1-ethoxycarbonylbutyl]-(S)-alanyl}-2-carboxy perhydroindole, its (S)-isomer or the sodium salt of these.
4.
A pharmaceutical composition containing as active ingredient at least one compound according to claim 1, in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier or excipient.
5.
A pharmaceutical composition containing as active ingredient a compound according to claim 3, in conjunction with an inert, non-toxic pharmaceutically-acceptable carrier or excipient.
6.
A method for treating a patient suffering from hypertension, which comprises administering to said patient a therapeutically effective dose of a compound according to claim 1.
7.
A method for treating a patient suffering from hypertension, which comprises administering to said patient a therapeutically-effective dose of a compound according to claim 3.




Description:
The present invention relates to new substituted imino-diacids, and more particularly to substituted azabicycloalkanedicarboxylic acids, their preparation and pharmaceutical compositions which contain them.
The invention relates specifically to the compounds having the general formula ##STR2## wherein: the ring A is saturated and n=0 or 1, or the ring A is a benzene ring and n=1, R.
sub.
1 represents a lower alkyl group having from 1 to 4 carbon atoms which can carry an amino group, R.
sub.
2 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R