 Process of making a synthetic resin product containing a molecular inclusion compound in cyclodextrin |
| Under these circumstances, the present invention provides a synthetic resin product containing a ... |
|
| Aminoalkylethers; composition and method of use |
| I claim: 1. Pharmaceutical compositions for treatment of Parkinsonism which comprise as active ... |
|
| Method of protecting useful plants and formulations for use in said method |
| What we claim is: 1. The method of combatting fungi infections of useful plants, or of preventing ... |
|
| Pharmaceutical preparation for treating hemorrhoids and anal fissures |
| What I claim is: 1. A pharmaceutical preparation of treating hemorrhoids and anal fissures, ... |
|
| Alkylated amine polymers |
| OF THE INVENTION Compositions Preferred reaction products include the products of one or more ... |
|
| Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
| OF THE INVENTION The lower alkyl groups referred to throughout this specification include straight ... |
|
| Tetrahydropyridine derivative useful for inhibiting blood platelet aggregation |
| What is claimed is: 1. A method for inhibiting the aggregation of blood platelets in a warm-blooded ... |
|
| Preparation of carbamates |
| We claim: 1. A compound of the formula ##STR3## wherein R" represents an acyl group conventionally ... |
|
| Substituted derivatives of 2-azabicyclo-[3.3.0]octanes |
| We claim: 1. A compound of the formula I ##STR140## in which n is a whole number between 0 and 3 ... |
|
|
Substituted phenylguanidines and method
| Details |
Inventors: Haugwitz, Rudiger D.; Maurer, Barbara V.;
Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ)
Primary Examiner: Shippen; Michael
Assistant Examiner:
Attorney, Agent or Firm: Levinson; Lawrence S., Rodney; Burton
Phenylguanidine derivatives are provided having the structure ##STR1## wherein R.sup.1 is lower alkyl, cycloalkylalkyl, or phenylalkyl; R.sup.2 is lower alkyl, phenyl or benzyl; and R.sup.3 is lower alkyl, cycloalkylalkyl, lower alkenylalkyl, dihalovinylalkyl, dihalobutadienyl or phenylalkyl; and n is 1 to 5. These compounds are useful as anthelmintic agents. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A compound of the structure ##STR34## wherein R.
sup.
1 is lower alkyl, cycloalkylalkyl, or phenylalkyl; R.
sup.
2 is lower alkyl, phenyl or benzyl; and R.
sup.
3 is lower alkyl, cycloalkylalkyl, lower alkenylalkyl, dihalovinylalkyl, dihalobutadienyl or phenylalkyl, and n is 1 to 5, and physiologically acceptable salts thereof.
2.
The compound as defined in claim 1 wherein n is 1.
3.
The compound as defined in claim 1 wherein n is 2.
4.
The compound as defined in claim 1 wherein R.
sup.
1 is lower alkyl, R.
sup.
2 is lower alkyl, R.
sup.
3 is lower alkyl and n is 1 or 2.
5.
The compound as defined in claim 1 having the name [[[2-[[(methylsulfinyl)acetyl]amino]-4-[(2-methylpropyl)sulfinyl]phenyl]am ino][(methoxy carbonyl)amino]methylene]carbamic acid, methyl ester.
6.
An anthelmintic composition comprising a therapeutic amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
7.
A method for treating or preventing helminth infestation in mammalian hosts which comprises administering to a mammal a therapeutic amount of an anthelmintic composition as defined in claim 1.
8.
The method as defined in claim 6 wherein said composition is administered orally or parenterally.
9.
The method as defined in claim 8 wherein said composition is administered parenterally.
Description:
DESCRIPTION OF THE INVENTION The present invention relates to phenylguanidine derivatives which are useful as anthelmintic agents and have the structure ##STR2## wherein R.
sup.
1 is lower alkyl, cycloalkylalkyl, or phenylalkyl; R.
sup.
2 is lower alkyl, phenyl or benzyl; R.
sup.
3 is lower alkyl, cycloalkylalkyl, lower alkenylalkyl, dihalovinylalkyl, dihalobutadienyl or phenylalkyl; and n is 1 to 5.
The term "lower alkyl" or "alkyl" as used herein whether employed as an independent substituent or as a part of another substituent includes straight or branched chain aliphatic hydrocarbon radicals having up to and including 7 carbon atoms, preferably 1 to 3 carbons, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, amyl, hexyl, heptyl and the like
|
| Related patents |
|
|
Cephalosporin derivatives
We claim: 1. A cephalosporin derivative of the formula ##STR153## in which n is 0 or 1, (a) the symbol R.sub.1 represents a radical of the formula ##STR154## in the syn ...
|
|
|
External preparations free of discoloration
What is claimed is: 1. A topical composition free of discoloration with the passage of time comprising at least 0.1 weight percent of kojic acid or a derivative thereof; ...
|
|
|
Cell-permeable protein inhibitors of calpain
The invention features methods of inhibiting a calpain (e.g., .mu.-calpain and/or m-calpain) in a cell (e.g., a eukaryotic cell). The method can be carried out, for ...
|
|
|
High molecular weight piperidine derivatives as UV stabilizers
I claim: 1. A compound of the formula ##STR3## wherein X is ##STR4## R being selected from alkyl of 1-6 carbon atoms; with R.sub.1 and R.sub.2 being independently ...
|
|
|
N.sup.2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof, and antithrombotic compositions and methods employing them
OF THE PREFERRED EMBODIMENTS This invention relates to a group of N.sup.2 -naphthalenesulfonyl-L-argininamides of the formula (I): ##STR2## wherein R.sub.1 is naphthyl, ...
|
|
|
Process for the production of sulfenamides
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. In a process for the production of a sulfenamide, in ...
|
|
|
Intermediates for triazolobenzazepines
What is claimed: 1. A compound of the formula ##STR6## wherein X and Y are hydrogen or halogen.
Description:
DESCRIPTION OF THE INVENTION The present ...
|
|
|
Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
OF THE INVENTION The invention provides a polypeptide which consists essentially of an amino acid sequence capable of specifically binding to the antigen to which ...
|
|
|
Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
We claim: 1. A compound selected from the group consisting of (1) a xanthene- and thioxanthene derivatives of the formula: ##STR54## wherein X is selected from the group ...
|
|
|
Sulfur and silicon-containing fatty acid amides
What is claimed is: 1. A compound of the formula: ##STR17## wherein each of R.sup.1, R.sup.2 and R.sup.3 is, independently, alkyl having from 1 to 22 carbon atoms, ...
|
|
|
Vasodialators 
