DETAILED DESCRIPTION OF THE INVENTION The novel substituted .
omega.
-aroyl(propionyl or butyryl)-L-prolines and esters thereof of the present invention are generally obtainable as white to yellow crystalline materials having characteristic melting points and absorption spectra or are obtained as white or yellow glasses with characteristic absorption spectra.
They are generally soluble in many organic solvents such as lower alkanols, tetrahydrofuran, dioxane, chloroform, and the like.
Also included within the purview of the present invention are the cationic salts of the compounds of the above general formulae wherein R.
sub.
5 is hydrogen.
The useful pharmaceutically acceptable salts of the compounds wherein R.
sub.
5 is hydrogen are those with pharmacologically acceptable metal cations, ammonium, amine cations, or quaternary ammonium cations.
Preferred metal cations are those derived from the alkali metals, e.
g.
lithium, sodium and potassium, and from the alkaline earth metals, e.
g.
magnesium and calcium, although cationic forms of other metals, e.
g.
aluminum, copper, iron and in particular zinc, are within the scope of the invention.
Pharmacologically acceptable amine cations are those derived from primary, secondary or tertiary amines such as mono-, di- or trimethylamine, ethylamine, dibutylamine, triisopropylamine, N-methylhexylamine, decylamine, allylamine, cyclopentylamine, dicyclohexylamine, mono- or dibenzylamine, .
alpha.
- or .
beta.
-phenylethylamine, ethylenediamine, and arylaliphatic amines containing up to and including 18 carbon atoms, as well as heterocyclic amines, e.
g.
piperidine, morpholine, pyrrolidine, piperazine and lower alkyl derivative thereof, e.
g.
1-methylpiperidine, 4-ethylmorpholine, 1-isopropylpyrrolidine, 1,4-dimethylpiperazine, and the like, as well as amines containing water-solubilizing or hydrophilic groups, e.
g.
mono-, di-, or triethanolamine, N-butylethanolamine, 2-amino- 1-butanol, 2-amino-2-ethyl-1,3-propanediol, tris(hydroxymethyl)aminomethane, N-phenylethanolamine, galactamine, N-methylglucosamine, ephedrine, phenylephrine, epinephrine, procaine, and the like
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