 Rat hypothalamic GRF |
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| 1-Ethoxy-3,4-dihydroisoquindines |
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| Method of labeling complex metal chelates with radioactive metal isotopes |
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| Process for the manufacture of an N-hydroxyalkylcarbazole |
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Tetrazolyl containing naphthyridine 3-carboxamides
| Details |
Inventors: Ellis, Gwynn Pennant; Collins, Ian; Waters, David Martin; Bays, David Edmund;
Assignee: Allen & Hanburys Limited (London, EN)
Primary Examiner: Jiles; Henry R.
Assistant Examiner: Ramsuer; R. W.
Attorney, Agent or Firm: Bacon & Thomas
Compounds of the general formulae I and II and pharmaceutically acceptable salts thereof: ##SPC1## In which: R.sub.1 represents a hydrogen atom, a halogen atom, an alkenyl or alkyl group; or a group OR.sub.3 or NR.sub.3 R.sub.4 where R.sub.3 and R.sub.4 which may be the same or different and may represent a hydrogen atom, or an alkenyl group, or an alkyl group which alkyl group may optionally be substituted by one or more hydroxy, alkoxy, acyloxy, aryl, amino, alkylamino, dialkylamino, diaralkylamino or alkylaralkylamino groups; or R.sub.3 and R.sub.4 together with the nitrogen atom form a 5 or 6 membered heterocyclic ring that may optionally contain other hetero atoms. R.sub.2 has the same meanings as R.sub.3. The compounds have utility for the treatment of conditions in which combination of an antigen with a reaginic antibody is primarily responsible. |
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DETAILED DESCRIPTION We claim: 1.
A compound of the formula ##SPC5## or the formula ##SPC6## in which R.
sub.
1 represents a hydrogen atom, a halogen atom, a C.
sub.
2 -.
sub.
6 alkenyl or a C.
sub.
1 -.
sub.
6 alkyl group; or a group OR.
sub.
3 or NR.
sub.
3 R.
sub.
4 where R.
sub.
3 and R.
sub.
4 which may be the same or different represent a hydrogen atom, a C.
sub.
2 -.
sub.
6 alkenyl group, a C.
sub.
1 -.
sub.
6 alkyl group or a C.
sub.
1 -C.
sub.
6 alkyl group substituted by at least one hydroxy, C.
sub.
1 -.
sub.
6 alkoxy group C.
sub.
1 -.
sub.
6 alkanoyloxy, phenyl, amino, C.
sub.
1 -.
sub.
6 alkylamimo, di C.
sub.
1 -.
sub.
6 alkylamino, diphenyl C.
sub.
1 -.
sub.
6 alkylamino or N,C.
sub.
1 -.
sub.
6 alkyl, N-phenyl-C.
sub.
1 -.
sub.
6 alkyl group, and R.
sub.
2 has the same meaning as R.
sub.
3 ; or a phramaceutically acceptable salt of a compound of formula I or II.
2.
A compound as claimed in claim 1 which is 1-ethyl-1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1,8-naphthyridine-3 -carboxamide.
3.
A compound as claimed in claim 1 which is 1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1,8-naphthyridine-3-carboxa mide.
4.
A compound as claimed in claim 1 which is 1(2-dimethylaminoethyl)-1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1,8 -naphthyridine-3-carboxamide.
5.
A compound as claimed in claim 1 which is 1-[2-(benzylmethylamino)ethyl]-1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5- yl)-1,8-naphthyridine-3-carboxamide.
6.
A compound as claimed in claim 1 which is 1-[2-dibenzylamino)ethyl]-1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1 ,8-naphthyridine-3-carboxamide.
7.
A compound as claimed in claim 1 which is 1,4-dihydro-7-methyl-4-oxo-1-(2-phenethyl)-N(1H-tetrazol-5-yl)-1,8-naphthy ridine-3-carboxamide.
8.
A compound as claimed in claim 1 which is 1,4-dihydro-1-isopropyl-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1,8-naphthyridi ne-3-carboxamide.
9.
A compound as claimed in claim 1 which is 1(2-formyloxyethyl)-1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1,8-nap hthyridine-3-carboxamide.
10.
A compound as claimed in claim 1 which is 1-allyl-1,4-dihydro-7-methyl-4-oxo-N(1H-tetrazol-5-yl)-1,8-naphthyridine-3 -carboxamide
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Vasodialators 
