Therapeutic substituted indole compounds and compositions thereof

DETAILED DESCRIPTION We claim: 1.
A compound of formula (I) ##STR39## wherein R, R.
sup.
1 and R.
sup.
2 are independently selected from hydrogen and C.
sub.
1-4 alkyl; R.
sup.
3 and R.
sup.
4 are independently selected from hydrogen, C.
sub.
1-6 alkyl, C.
sub.
3-6 cycloalkyl, aryl, and benzyl, wherein the alkyl, cycloalkyl, aryl or benzyl group is optionally substituted by one or more atoms or groups independently selected from halogen, C.
sub.
1-4 alkyl and aryl, provided R.
sup.
3 .
noteq.
benzyl or substituted benzyl when R.
sup.
4 =H; m is an integer of from 0 to 2; n is an integer of from 0 to 3; (W) is a group of formula (i), (ii), (iii) or (iv) ##STR40## wherein, in formulae (i) and (ii), R.
sup.
5 is hydrogen, C.
sub.
1-4 alkyl or benzyl, and the chiral center *in formula (i) or (ii) is in its (S) or (R) form or is mixture thereof in any proportions; X is phenyl which group is optionally substituted by an atom or group selected from C.
sub.
1-6 alkyl C.
sub.
3-6 cycloalkyl phenyl C.
sub.
1-4 alkoxy phenoxy alkylsulphonyl phenylsulphonyl halogen cyano carbamoyl alkylcarbamoyl dialkylcarbamoyl phenylcarbamoyl diphenylcarbamoyl carbamoylmethyl N-alkylcarbamoylmethyl N,N-dialkylcarbamoylmethyl N-phenylcarbamoylmethyl N,N-diphenylcarbamoylmethyl alkoylamino benzoylamino alkoylaminomethyl benzoylaminomethyl alkylsulphamino phenylsulphamino alkylsulphaminomethyl phenylsulphaminomethyl sulphamyl alkylsulphamyl dialkylsulphamyl phenylsulphamyl or diphenylsulphamyl the phenyl group(s) of phenyl-containing substituents being optionally substituted by halogen or C.
sub.
1-4 alkoxy; or a salt or solvate thereof.
2.
A compound of formula (I) as claimed in claim 1, or a salt or solvate thereof, in which (W) is (i) wherein Y=0, CH.
sub.
2, or NR.
sup.
5, Z=CO or CH.
sub.
2 and Z'=CO, (W) is (ii) wherein Y=CH.
sub.
2 or NR.
sup.
5 and Z=Z'=CO, (W) is (iii) wherein Y=CH.
sub.
2 or NR.
sup.
5, Z=CO and Z'=CO or CH.
sub.
2, or (W) is (iv) wherein Y=CH.
sub.
2, Z=CO and Z'=CO or CH.
sub.
2, and X is a phenyl ring substituted by an alkylcarbamoyl, alkoylamino, or alkylsulphamino group