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Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
| Details |
Inventors: Scheinberg, David A.;
Assignee: Sloan-Kettering Institute for Cancer Research (New York, NY)
Primary Examiner: Scheiner; Toni R.
Assistant Examiner: Johnson; Nancy A.
Attorney, Agent or Firm: White; John P. Cooper & Dunham LLP
Therapeutic agents and methods for treating and diagnosing leukemia are provided. Such agents comprises monoclonal antibody M195, a polypeptide capable of binding to the antigen of M195, or a chimeric antibody such a peptide, conjugated to a cytotoxic agent, e.g. a radioisotope or alone. Methods for delivering genetic information to a targeted cell is also provided. |
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DETAILED DESCRIPTION OF THE INVENTION The invention provides a polypeptide which consists essentially of an amino acid sequence capable of specifically binding to the antigen to which monoclonal antibody M195 (ATCC No.
HB 10306) binds, for example, an amino acid sequence which consists essentially of the amino acids of the hypervariable region of monoclonal antibody M195 which are necessary for binding to the antigen.
In one embodiment, the polypeptide consists essentially of an amino acid sequence which is the same, or substantially the same, as the amino acid sequence of the hypervariable region of mouse monoclonal antibody M195.
The hybridoma which produces the monoclonal antibody designated M195 has been deposited on Dec.
12, 1989 with the American Type Culture Collection (ATCC) 12301 Parklawn Drive, Rockville, Md.
, U.
S.
A.
20852, under ATCC Accession No.
HB 10306.
This deposit was made pursuant to the provisions of the Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purposes of Patent Procedure (Budapest Treaty).
Thus, one may obtain a polypeptide of the type described hereinabove by first obtaining monoclonal antibody M195 from the deposited hybridoma and then treating the M195 antibody so as to obtain from it the hypervariable region, e.
g.
by proteolytic digestion.
Alternatively, one may clone the DNA which encodes the hypervariable region of the M195 antibody and express the DNA, using standard recombinant DNA procedures, in a suitable unicellular or other host.
In this way one may obtain a polypeptide within the scope of the invention.
Further, the polypeptide may be synthesized using well known techniques for synthesizing polypeptides, by chemical procedures.
The subject invention is not limited to polypeptides which contain an amino acid sequence which corresponds to the hypervariable region of the M195 antibody.
The invention also embraces polypeptides which consist essentially of an amino acids sequence capable of specifically binding to the same antigen, i
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Vasodialators 
