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Therapeutically active phenoxyalkylamines
| Details |
Inventors: Petersen, Rudolf Theodor; Fleck, Wolfgang;
Assignee: Biersdorf Aktiengesellschaft (Hamburg, DT)
Primary Examiner: Randolph; John D.
Assistant Examiner:
Attorney, Agent or Firm: Stevens, Davis, Miller & Mosher
Compounds of the formula: ##STR1## (wherein R.sub.1 represents a chlorine atom or a methoxy or cyano group; R.sub.2 represents a hydrogen atom or a methyl or hydroxy group; m is 2, 3 or 4; and n is 1 or 2) And their physiologically acceptable acid addition salts have blood pressure reducing properties and may be used in the treatment of patients. |
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DETAILED DESCRIPTION We claim: 1.
Compounds of the formula I: ##STR6## wherein R.
sub.
1 represents a cyano group; R.
sub.
2 represents a hydrogen atom or a methyl or hydroxy group; m is 2, 3 or 4; and n is 1 or 2 and their physiologically acceptable acid addition salts.
2.
Compound according to claim 1 which is N-[(3-methyl-2-pyridyl)-methyl]-o-cyano-phenoxyethylamine or a physiologically acceptable acid addition salt thereof.
3.
Compound according to claim 1 which is N-[4-pyridyl-ethyl (2)]-o-cyano-phenoxyethylamine or a physiologically acceptable acid addition salt thereof.
Description:
This invention relates to therapeutically active phenoxyalkylamines.
According to the present invention there are provided compounds of the formula I: ##STR2## wherein R.
sub.
1 represents a chlorine atom or a methoxy or cyano group; R.
sub.
2 represents a hydrogen atom or a methyl or hydroxy group; m is 2, 3 or 4; and n is 1 or 2 And their physiologically acceptable acid addition salts.
The compounds of formula I and their physiologically acceptable acid addition salts have valuable pharmacological properties.
In particular they have blood pressure reducing properties and generate, after administration to rats with artificially promoted high pressure, a marked diminution in blood pressure of long duration.
They may be administered perorally.
Further they are of low toxicity.
They are therefore suitable as therapeutic agents particularly for treating cronic high blood pressure.
The compounds of formula I can be used as such but are preferably used in the form of their good crystallising acid addition salts.
Compounds of formula I (including their physiologically acceptable acid addition salts) which may be mentioned include N-[4-Pyridyl-ethyl(2)]-o-methoxy-phenoxyethylamine; N-[2-Pyridyl-ethyl(2)]-o-methoxy-phenoxyethylamine; N-(3-Pyridyl-methyl)-o-methoxy-phenoxyethylamine; N-(2-Pyridyl-methyl)-o-methoxy-phenoxyethylamine; N-(4-Pyridyl-methyl)-o-methoxy-phenoxyethylamine; N-[4-Pyridyl-ethyl (2)]-o-chloro-phenoxypropylamine; N-[4-Pyridyl-ethyl (2)]-o-chloro-phenoxyethylamine; N-[(3-Methyl-2-pyridyl)-methyl]-o-chloro-phenoxyethylamine; N-[(3-Methyl-2-pyridyl)-methyl]-o-cyano-phenoxyethylamine; N-[4-Pyridyl-ethyl (2) ]-o-chloro-phenoxybutylamine; N-[4-Pyridyl-ethyl (2)]-o-cyano-phenoxyethylamine; and N-[(3-Hydroxy-2-pyridyl)-methyl]-o-methoxy-phenoxyethylamine
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Vasodialators 
