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Treatment for osteoporosis
| Details |
Inventors: Tsuda, Masao; Sawa, Yoichi; Yamazaki, Iwao;
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Primary Examiner: Chan; Nicky
Assistant Examiner:
Attorney, Agent or Firm: Wegner & Bretschneider
A compound of the formula ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl and Y is carboxyl or a group convertible to carboxyl is effective for prevention or treatment of osteoporosis. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A method for prevention or treatment of osteoporosis, which comprises administering to a patient in need of such prevention or treatment, as an active ingredient, an effective amount of a compound of the formula ##STR5## wherein R.
sup.
1 is hydrogen or hydroxy, R.
sup.
2 and R.
sup.
3 are independently hydrogen or lower alkyl and Y is carboxyl, (C.
sub.
1-4 -alkoxy)carbonyl, benzyloxy-carbonyl, phenyloxycarbonyl, carbamoyl, N-methylcarbamoyl, N-ethycarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-morpholinocarbonyl, N-piperidinocarbonyl or N-piperazinocarbonyl.
2.
A method for prevention or treatment of osteoporosis, which comprises administering to a patient in need of such prevention or treatment, as an active ingredient, an effective amount of a compound of the formula ##STR6## wherein R.
sup.
1 is hydrogen or hydroxy, R.
sup.
2 and R.
sup.
3 are independently hydrogen or lower alkyl and Y is carboxyl or C.
sub.
1-4 -(alkoxy)carbonyl.
3.
A method for prevention or treatment of osteoporosis of claim 1, which comprises administering to a patient in need of such prevention or treatment, as an active ingredient, an effective amount of a compound of the formula ##STR7## wherein R.
sup.
1 is hydrogen or hydroxy, R.
sup.
2 is hydroqen, R.
sup.
3 is lower alkyl and Y is carboxyl or lower alkoxycarbonyl.
4.
A method of claim 1, wherein the compound to be administered is 7-(1-hydroxycarbonylethyl) oxy-3-phenyl-4H-1-benzopyran-4-one.
5.
A method of claim 1, wherein the compound to be administered is 7-(1-hydroxycarbonylethyl) oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one.
6.
A method of claim 1, wherein the compound to be administered is 7-(1-ethoxycarbonylethyl) oxy-3-phenyl-4H-1-benzopyran-4-one.
7.
A method of claim 1, wherein the compound to be administered is 7-(1-ethoxycarbonylethyl) oxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one.
8.
A method of claim 1, wherein the patient in need of such prevention or treatment is elderly.
9.
A method of claim 1, wherein administration of the compound is conducted orally in a daily dose of from about 10 to about 500 mg for an adult human
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