Use of fedotozine in the treatment of functional states of intestinal obstructions

DETAILED DESCRIPTION We claim: 1.
Process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethylpropylamine or the addition salt thereof with (-)-tartaric acid.
2.
Process according to claim 1, in which the functional ileus is postoperative.
3.
Process according to claim 1, in which the functional ileus is of pseudo-obstructive origin.
4.
Process according to claim 1 which consists in administering a daily dose of 5 to 1000 mg to the patient.
5.
Process according to claim 1, which consists in administering the substance by injection.
6.
Process according to claim 1, which consists in administering the substance by perfusion.




Description:
In gastroenterology it is known that functional occlusions observed at different stages of the gastrointestinal tract result in a motor paralysis of the digestive tract.
These states, known as ileus, are always observed, inter alia, after certain surgical operations, especially laparotomies.
They may also be encountered in localised functional occlusive disorders such as pseudo obstructions of the colon (Ogilvie syndrome), more extensive occlusions such as chronic iodapathic pseudo obstruction which corresponds to a true gastrointestinal paralysis, or in various retroperitoneal disorders such as nephritic colics, in which persistent ileus may be established, linked with peritoneal irritation.
Whatever the ethiologic circumstances, these ileus result in a build-up of gases and secretions which cause painful abdominal meteorism, nausea and vomiting in the patient.
A distinction is drawn depending on the duration of these states, which is about 72 hours for "simple" or "physiologic" post-operative ileus and up to several weeks for cases of paralytic ileus where an underlying trouble, for instance a hydroelectric trouble should be investigated.
The latter cases are the more serious and the patent frequently has respiratory problems linked with the meteorism and the conditions of dehydration for which the symptomatic medical treatment in a hospital environment consists of inserting a nasointestinal tube, in conjunction with rehydration of the patient by intravenous route until the ileus is resolved