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| Latest patents |
Results: 31-60 of 1119
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Controlled release formulation
What is claimed is: 1. In a controlled release angiotensin converting enzyme inhibitor formulation in the form of an uncoated tablet from which upon ingestion angiotension converting enzyme inhibitor ... Read More
Inventors: DeCrosta, Mark T.; Jain, Nemichand B.; Rudnic, Edward M.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Formulations providing three distinct releases
We claim: 1. A therapeutic composition for oral administration consisting essentially of a pharmaceutical gelatin capsule containing film coated spheroids, which spheroids prior to coating comprise 10... Read More
Inventors: Mehta, Atul M.; Bachand, Lizbeth A.; Leonard, Thomas W.; Warner, Ronald N.;, Assignee: American Home Products Corporation (New York, NY) |
Floating sustained release therapeutic compositions
OF THE INVENTION According to the present invention, therapeutic dosage forms have now been discovered which are easy to prepare, provide sustained release of contained therapeutic agents and float o... Read More
Inventors: Bolton, Sanford; Desai, Subhash;, Assignee: St. John's University (New York, NY) |
Solid oral dosage forms of ifosfamide
OF PREFERRED EMBODIMENTS The invention is illustrated by the following examples: EXAMPLE 1 Ifosfamide capsule mass In accordance with the invention, the capsule mass is for example manufactured accor... Read More
Inventors: Sauerbier, Dieter; Engel, Jurgen; Milsmann, Eckhard; Molge, Klaus; Isaac, Otto;, Assignee: Asta Medica Aktiengesellschaft (DE) |
[(benzodioxan, benzofuran or benzopyran) alkylamino] alkyl substituted guanidines
We claim: 1. A compound of the formula: ##STR259## a pharmaceutically acceptable acid addition salt thereof, or a stereochemically isomeric form thereof, wherein: X is O, CH.sub.2 or a direct bond; R.... Read More
Inventors: Van Lommen, Guy R. E.; De Bruyn, Marcel F. L.; Janssens, Walter J. J.;, Assignee: Janssen Pharmaceutica N.V. (Beerse, BE) |
Methods for treating dermatitis using descarboethoxyloratadine
OF THE INVENTION The present invention encompasses a method of treating allergic asthma in a human while avoiding the concomitant liability of adverse side-effects associated with the administration ... Read More
Inventors: Handley, Dean A.; Rubin, Paul D.;, Assignee: Sepracor Inc. (Marlborough, MA) |
Fat emulsions containing isocarbacyclin
What is claimed is: 1. A pharmaceutical prostaglandin emulsion comprising: a mixture of vegetable oil, phospholipid, water, and a pharmaceutically effective amount of at least one compound of formula ... Read More
Inventors: Mizushima, Yutaka; Shoji, Yoko; Yagyu, Yasuko; Kurozumi, Seizi;, Assignee: Teijin Limited (Osaka, JP); Mizushima; Yutaka (Tokyo, JP) |
Dermal pharmaceutical preparations
OF THE INVENTION The support which can be used in the present invention functions to retain a layer of a pressure-sensitive adhesive containing a drug and is selected from materials having moderate s... Read More
Inventors: Hosaka, Yoshifumi; Otsuka, Saburo; Kinoshita, Takashi; Ito, Yusuke;, Assignee: Nitto Electric Industrial Co., Ltd. (Osaka, JP) |
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
We claim: 1. A compound selected from the group consisting of iminodiacid compounds having the formula: ##STR20## wherein R.sub.1 represents lower-alkyl having 1 to 4 carbon atoms, inclusive, R.sub.2 ... Read More
Inventors: Vincent, Michel; Remond, Georges; Laubie, Michel;, Assignee: Adir (Neuilly-sur-Seine, FR) |
2-Azasfiro[4.(3+N)]-3-carboxylic acid derivatives, a process for their preparation, agents containing these derivatives and their use
We claim: 1. A compound of the formula I ##STR11## in which n denotes 1, 2, 3 or 4, R denotes (C.sub.1 -C.sub.6)-alkyl, (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.9)-cycloalkyl, (C.sub.6 -C.sub.12)-a... Read More
Inventors: Teetz, Volker; Urbach, Hansjorg; Becker, Reinhard;, Assignee: Hoechst Aktiengesellschaft (DE) |
N-Acyl hexahydroindole-2-carboxylic acids and anti-hypertensive use thereof
We claim: 1. A compound of the formula I, ##STR24## in which n denotes 0 to 1, R denotes hydrogen, (C.sub.1 to C.sub.6)-alkyl or aralkyl having 7 to 9 C atoms, R.sup.1 denotes hydrogen or (C.sub.1 to ... Read More
Inventors: Urbach, Hansjorg; Henning, Rainer; Teetz, Volker; Wissmann, Hans; Becker, Reinhard;, Assignee: Hoechst Aktiengesellschaft (Frankfurt, DE) |
Bicyclic amino acids as intermediates in the preparation of tricyclic amino acids and processes for their preparation
We claim: 1. A compound of the formula III ##STR19## in which A denotes --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, the H atoms on C-2 and C-6 are in the cis-configuration relative to one another, the ... Read More
Inventors: Urbach, Hansjorg; Henning, Rainer; Becker, Reinhard;, Assignee: Hoechst Aktiengesellschaft (DE) |
Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
OF THE INVENTION AND PREFERRED EMBODIMENTS In its broadest aspect, the present invention relates to novel substituted N-carboxymethyl-aminoacylaminoalkanoic acid compounds of the formula: ##STR3## wh... Read More
Inventors: Parsons, William H.; Taub, David;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Racemates of optically active bicyclic imino-alpha-carboxylic esters
We claim: 1. A diasteromic salt of i. a bicyclic imino-.alpha.-carboxylic ester of the formulae Ia or Ib ##STR15## in which the two bridgehead hydrogen atoms have the cis configuration, the COOR group... Read More
Inventors: Geiger, Rolf; Teetz, Volker; Langner, Dietrich;, Assignee: Hoechst Aktiengesellschaft (DE) |
Disubstituted proline derivatives
We claim: 1. A compound of the formula I ##STR15## in which R.sup.1 and R.sup.2 together represent one of the chains --(CH.sub.2).sub.n -- or --(CH.sub.2).sub.p --CH.dbd.CH--(CH.sub.2).sub.q, n, p and... Read More
Inventors: Henning, Rainer; Urbach, Hansjorg;, Assignee: Hoechst Aktiengesellschaft (Frankfurt, DE) |
Derivatives of cis, endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid, and their use for treating hypertension
We claim: 1. A compound of the formula I ##STR11## in which the hydrogen atoms on the bridgehead C atoms 1 and 5 have the cis-configuration relative to one another and the carboxyl group on C atom 3 i... Read More
Inventors: Urbach, Hansjorg; Henning, Rainer; Teetz, Volker; Becker, Reinhard;, Assignee: Hoechst Aktiengesellschaft (DE) |
Carboxyalkyl dipeptides and anti-hypertensive use thereof
We claim: 1. A compound represented by the formula ##STR12## and the pharmaceutically acceptable salts thereof, wherein R and R.sup.6 are the same or different and are hydroxy or lower alkoxy; R.sup.1... Read More
Inventors: Gold, Elijah H.; Neustadt, Bernard R.; Smith, Elizabeth M.;, Assignee: Schering Corporation (Kenilworth, NJ) |
Optically active bicyclic imino-alpha-carboxylic esters
We claim: 1. A compound of the formulae Ia or Ib essentially free of its racemate, and salts of said compound, ##STR15## in which the two bridgehead hydrogen atoms have the cis configuration, the COOR... Read More
Inventors: Geiger, Rolf; Teetz, Volker; Langner, Dietrich; Urbach, Hansjorg; Henning, Rainer;, Assignee: Hoechst Aktiengesellschaft (DE) |
5-HT.sub.3 receptor antagonists for treatment of cough and bronchoconstriction
I claim: 1. A method of treatment of cough and/or bronchoconstriction in mammals, which method comprises the administration to the mammal in need of such treatment, an effective amount of a 5-HT.sub.3... Read More
Inventors: Williams, Andrew J.;, Assignee: Beecham Group, p.l.c. (Middlesex, GB2) |
Therapeutic compositions with enhanced bioavailability
OF THE INVENTION This invention relates to compositions of a drug with a water soluble polymer which has been treated with a wetting sufficient amount of a wetting agent selected from anionic and cat... Read More
Inventors: Martin, Frederick H.; Tsuk, Andrew G.;, Assignee: American Home Products Corporation (New York, NY) |
Medicament adsorbates and their preparation
In particular, it has been found that a good tasting medicament adsorbate is produced from admixing about 1 to about 25% by weight of a medicament drug with about 8 to about 50% by weight of a melted... Read More
Inventors: Mozda, Ronald F.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Sustained release formulations
We claim: 1. In combination, a drug suitable for oral delivery and a delivery system for sustained release dosage of said drug comprising: (a) a core portion containing about 70 to 90% by weight of th... Read More
Inventors: Phillips, Reginald; Bikkina, Krishnayya; Khan, Sadath U.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Water dispersible gemfibrozil compositions
What is claimed is: 1. A water-dispersible formulation of gemfibrozil comprising finely divided particles of pure gemfibrozil uniformly coated with a mixture of a wax and at least one hydrophilic mate... Read More
Inventors: Ghebre-Sellassie, Isaac; Gordon, Robert H.; Iyer, Uma; Fawzi, Mahdi B.;, Assignee: Warner-Lambert Company (Ann Arbor, MI) |
Method and composition for enhancing the effect of indirect-acting sympathomimetic amines
OF SPECIFIC EMBODIMENTS In accordance with this invention, tyrosine or a tyrosine precursor such as phenylalanine is administered concomitnatly with an indirect-acting sympathomimetic amine drug, the... Read More
Inventors: Wurtman, Richard J.; Maher, Timothy J.;, Assignee: Massachusetts Institute of Technology (Cambridge, MA) |
1-azabicycloalkane derivatives, their preparation process and their use as medicaments
What is claimed is: 1. A compound of formula (I) ##STR5## in which n represents the number 1, R.sub.1 and R.sub.2, identical or different represent hydrogen or an unsubstituted or substituted member o... Read More
Inventors: Galliani, Giulio; Barzaghi, Fernando; Bonetti, Carla; Toja, Emilio;, Assignee: Roussel UCLAF (Paris, FR) |
Use of specific N-methyl-D-aspartate receptor antagonists in the prevention and treatment of neurodegeneration
OF THE INVENTION The novel method of treatment of neurodegeneration of this invention comprises the administration to a patient in need of such treatment with an effective amount of an N-methyl-D-asp... Read More
Inventors: Woodruff, Geoffrey N.; Wong, Erik H. F.; Kemp, John A.;, Assignee: Merck Sharp & Dohme Limited (Hoddesdon, GB2) |
Iron citrate complex, process for its production, and its pharmaceutical
We claim: 1. An iron citrate micellar complex, which is a brown solid having the properties set out below: (a) average composition by weight of about: 10.6% carbon, 2.62% hydrogen, 50.2% oxygen, 32% i... Read More
Inventors: Vidic, Hans-Jorg; Antonini, deceased, Eraldo;, Assignee: Schering Aktiengesellschaft (Berlin and Bergkamen, DE) |
Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and pharmaceutical composition containing the same
OF INVENTION The 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles of the present invention have the formula (I) as described hereinbefore. In the formula (I), the groups for the symbol R.sup.1 inclu... Read More
Inventors: Yoshino, Koichiro; Seko, Norihiko; Yokota, Koichi; Ito, Keizo; Tsukamoto, Goro;, Assignee: Kanebo, Ltd. (Tokyo, JP) |
Specifically .beta.-.beta. cross-linked hemoglobins and method of preparation
The present invention provides a modified hemoglobin comprising hemoglobin which is cross-linked with a cross-linking reagent, said cross-linking reagent being selected such that the .beta.-chains are... Read More
Inventors: Kluger, Ronald; Wodzinska, Jolanta;, Assignee: The University of Toronto Innovations Foundation (Toronto, CA) |
Apparatus for manufacturing granulated material
The invention proceeds from the consideration that it is not possible to reduce the width of the slit, especially at high production rates i.e., at high relative velocities between the perforated belt... Read More
Inventors: Froeschke, Reinhard; Konig, Axel;, Assignee: Santrade Ltd. (Lucerne, CH) |
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Vasodialators 
