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| Latest patents |
Results: 301-330 of 1119
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7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
OF THE INVENTION As used herein, "alkanyl" means a saturated hydrocarbon substituent, straight or branched chain, unsubstituted or substituted. As used herein, "alkenyl" means a hydrocarbon substitue... Read More
Inventors: Cupps, Thomas Lee; Bogdan, Sophie Eva;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Process for the preparation of halo aromatic compounds
What is claimed is: 1. A process for the preparation of 3-chloro-4,5-difluorobenzotrifluoride which comprises the steps of (A) reacting an alkali metal fluoride with 4-chloro-3,5-dinitrobenzotrifluori... Read More
Inventors: Maul, James J.; Tang, David Y.;, Assignee: Occidental Chemical Corporation (Niagara Falls, NY) |
5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
We claim: 1. A method of treating warm-blooded animals suffering from leukotriene-mediated diseases and disorders by administering an effective 5-lipoxygenase inhibiting amount of a compound of formul... Read More
Inventors: Van Wauwe, Jean P. F.; Heeres, Jan; Backx, Leo J. J.;, Assignee: Janssen Pharmaceutica N.V. (Beerse, BE) |
Process for preparing methotrexate or an N-substituted derivative thereof and/or a di (lower) alkyl ester thereof and precursor therefor
I claim: 1. A process for preparing a compound having the formula: ##STR10## wherein R is hydrogen or a lower alkyl group and R' is hydrogen or a methyl group which consists essentially of the steps o... Read More
Inventors: Wiecko, Jacek;, Assignee: |
Medicaments having antihypoxic and ischaemia-protective activity
We claim: 1. A method of controlling damage to the central nervous system of a patient requiring such treatment which comprises administering to such patient a central nervous system-controlling effec... Read More
Inventors: Wehinger, Egbert; Meyer, Horst; Benz, Ulrich;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity
We claim: 1. An asymmetrical compound of the formula ##STR58## in which R represents phenyl or naphthyl optionally containing 1 to 2 identical or different substituents from the group consisting of ph... Read More
Inventors: Wehinger, Egbert; Meyer, Horst; Knorr, Andreas;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
Mitomycin analogs
What is claimed is: 1. A method for treatment of a neoplastic disease state in an animal comprising administering to an animal having such a disease a therapeutically effective amount of a compound of... Read More
Inventors: Remers, William A.;, Assignee: University Patents, Inc. (Westport, CT) |
Anhydrous antiperspirant creams
OF THE INVENTION The substantially anhydrous antiperspirant cream compositions of the present invention essentially comprise a liquid emollient, an inorganic clay thickening/suspending agent, a gel-p... Read More
Inventors: Shelton, David Lee;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
One-phase silicone-based cosmetic products containing wax
OF THE INVENTION Cosmetic compositions in accordance with this invention include 2 to 50 wt. %, preferably 10 to 40 wt. %, and more preferably 20 to 40 wt. %, of dimethylpolysiloxane having the formu... Read More
Inventors: Tietjen, Marlene; Hollenberg, Jane; Rigg, Richard T.;, Assignee: Revlon, Inc. (New York, NY) |
Process for preparing concentrated aluminum-zirconium solutions
What is claimed is: 1. A method for producing concentrated aluminum-zirconium glycine solutions consisting essentially of (A) forming a zirconium chloride complex by heating aqueous zirconium chloride... Read More
Inventors: Carmody, Walter J.;, Assignee: Somerville Technology Group, Inc. (Somerset, NJ) |
Vaso-dilating and coronary active 4-nitrophenyl-tetrahydropyridines
We claim: 1. A 4-(nitrophenyl)-1,2,3,4-tetrahydropyridine of the formula ##STR16## in which R.sub.1 and R.sub.2 are identical or different and each represent hydrogen, phenyl or a straight-chain or br... Read More
Inventors: Ulrich, Rosentreter; Thomas, Gunter; Knorr, Andreas;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
Hair fixatives comprising silanes containing a silsesquioxane characteristic
OF THE INVENTION As noted above, the present invention relates to hair fixatives which utilize as the film forming ingredient a pre-hydrolyzed organofunctional silane having silsesquioxane characteri... Read More
Inventors: Halloran, Daniel J.; Vincent, Judith M.;, Assignee: Dow Corning Corporation (Midland, MI) |
1,2,3,4-Tetrahydroisoquinolines and the preparation thereof
What we claim is: 1. 1,2,3,4-Tetrahydroisoquinolines of the formula: ##STR7## wherein R is tetrazolyl, pyridyl, pyrimidinyl, thiadiazolyl or benzimidazolyl, each of which may be substituted by C.sub.1... Read More
Inventors: Kishimoto, Teiji; Ueda, Ikuo; Kato, Masayuki;, Assignee: Fujisawa Pharmaceutical Co., Ltd. (Osaka, JA) |
1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system
We claim: 1. A 1-aryl 2-aminomethyl cyclopropane carboxamide (Z) of the formula I: ##STR23## in which: R represents hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, nitro, or amino; n represents... Read More
Inventors: Mouzin, Gilbert; Cousse, Henri; Bonnaud, Bernard; Morre, Michel; Stenger, Antoine;, Assignee: Pierre Fabre S.A. (Castres, FR) |
Pyridyl alkylthiourea and alkylamino-nitroethylene
We claim: 1. A compound of the formula: ##STR19## wherein X is sulphur or CHNO.sub.2 ; Y is amino, lower alkylamino, di(lower alkyl)amino, lower alkoxy, phenylethyl, allyl, 2,2,2-trifluoroethyl, or (C... Read More
Inventors: Durant, Graham J.; Ganellin, Charon R.; Owen, Geoffrey R.; Young, Rodney C.;, Assignee: Smith Kline & French Laboratories Limited (Welwyn Garden City, GB2) |
Quinone derivatives, their production and use
What we claim is: 1. A compound of the formula: ##STR94## wherein n is an integer of 1 to 10, R.sup.1 is methyl or methoxy, or two of R.sup.1 combine to represent --CH.dbd.CH--CH.dbd.CH--, and R.sup.2... Read More
Inventors: Terao, Shinji; Shiraishi, Mitsuru; Kato, Kaneyoshi;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP) |
5-oxo-2-pyrrolidinepropanoic acid derivatives and use as cognition activators
I claim: 1. A compound having the structural formula ##STR13## wherein R is selected from ##STR14## where R' is amino, alkylamino, or dialkylamino of from one to six carbon atoms. 2. The compound defi... Read More
Inventors: Butler, Donald E.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
5-Halopyrimid-2-ones
What we claim is: 1. A compound of the formula: ##STR16## wherein X represents a fluorine, chlorine or bromine atom; R.sup.1 and R.sup.2, which may be the same or different, each represent hydrogen or... Read More
Inventors: Gacek, Mikkel J.; Oftebro, Reidar; Laland, Soren; Undheim, Kjell;, Assignee: Nyegaard & Co. A/S (NO) |
Substituted cinnamoyl-piperazine-pyridyl compound
We claim: 1. A compound of the formula ##SPC3## wherein X represents a carbonyl group >C=O or a methylene group --CH.sub.2 --, R represents a phenyl, mono- or di-halophenyl or 2-pyridyl group, R.su... Read More
Inventors: Szabo, Suzanne; Molnar, Francois; Mauvernay, Roland-Yves; Levan, Chau; Statkov, Peter Radanov; Straumann, Danielle; Lerik Milovanovic, Olga;, Assignee: Cermol S.A. () |
Heterocyclic derivatives of (4-phenyl-piperazine-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imi dazoles and 1H-1,2,4-triazoles
What is claimed is: 1. A chemical compound selected from the group consisting of an azole derivative having the formula: ##STR68## and the pharmaceutically acceptable acid addition salts and stereoche... Read More
Inventors: Heeres, Jan; Backx, Leo J. J.;, Assignee: Janssen Pharmaceutica N.V. (Beerse, BE) |
Diaminopropanols
I claim: 1. A compound of the formula ##SPC4## wherein R.sub.1 and R.sub.2 are Hydrogen, chlorine, fluorine, methyl, trifluoromethyl, methoxy, or when taken together, represent a methylenedioxy group;... Read More
Inventors: Jacquier, Robert R.;, Assignee: Centre d'Etudes pour l'Industrie Pharmaceutique (Toulouse, FR) |
Enlarged-hetero-ring prostacylin analogs
I claim: 1. A 5Z compound of the formula ##STR20## wherein R.sub.20 is ##STR21## wherein L is (1) --(CH.sub.2).sub.d --C(R.sub.2).sub.2 -- (2) --CH.sub.2 --O--CH.sub.2 --Y-- or (3) --CH.sub.2 CH.dbd.C... Read More
Inventors: Kelly, Robert C.;, Assignee: The Upjohn Company (Kalamazoo, MI) |
Quaternary ammonium co-polymers for controlling the proliferation of bacteria
The invention claimed is: 1. A method of controlling the proliferation of bacteria which comprises applying to said bacteria an effective amount sufficient to inhibit their growth, of a product formed... Read More
Inventors: Green, Harold A.; Merianos, John J.; Petrocci, Alfonso N.;, Assignee: Millmaster Onyx Corporation (New York, NY) |
Microbiocidal polymeric quaternary ammonium compounds
The invention claimed is: 1. A method of controlling the proliferation of fungi in a water-in-oil emulsion which comprises incorporating into said emulsion as a fungicidal agent a condensation product... Read More
Inventors: Green, Harold A.; Merianos, John J.; Petrocci, Alfonso N.;, Assignee: Millmaster Onyx Corporation (New York, NY) |
Anti-microbial quaternary ammonium co-polymers
The invention claimed is: 1. A product formed by the condensation of a mixture of difunctional tertiary amines and a molar quantity of 1,4-dichloro-2-butene that is substantially equal to the molar su... Read More
Inventors: Green, Harold A.; Merianos, John J.; Petrocci, Alfonso N.;, Assignee: Millmaster Onyx Corporation (New York, NY) |
Soft contact lens preserving solutions
We claim: 1. A method of sterilizing soft contact lenses comprising contacting a soft contact lens with an effective amount of a sterile, aqueous, non-toxic composition comprising about 0.01 to about ... Read More
Inventors: Blanco, Milagros V.; Maurer, David L.;, Assignee: Allergan Pharmaceuticals (Irvine, CA) |
Randomly terminated capped polymers
The invention claimed is: 1. A polymeric quaternary ammonium compound and mixtures thereof of formula: ##STR3## wherein Z represents either (1) a divalent aliphatic radical of from 2 to 10 carbon atom... Read More
Inventors: Green, Harold A.; Merianos, John J.; Petrocci, Alfonso N.;, Assignee: Kewanee Industries, Inc. (Bryn Mawr, PA) |
Antiinflammatory analgesic gelled ointment
OF THE PREFERRED EMBODIMENTS Suitable hydroxy compounds useful in the invention include glycols such as propylene glycol, butylene glycol, polyethylene glycol and the like, and alcohols such as ethan... Read More
Inventors: Inagi, Toshio; Muramatsu, Toyojiro; Nagai, Hidetaka;, Assignee: Kowa Company Limited (Nagoya, JP) |
Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
We claim: 1. A method for the treatment of glaucoma or ocular hypertension which comprises contacting the eye with a composition containing an ophthalmologically compatible vehicle and an effective in... Read More
Inventors: Stjernschantz, Johan W.; Resul, Bahram;, Assignee: Kabi Pharmacia AB (Uppsala, SE) |
Fungicides aromatic oxime amides
We claim: 1. A compound having the formula (I): and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkoxy, C.sub.1-4... Read More
Inventors: Clough, John M.; Godfrey, Christopher R. A.; de Fraine, Paul J.; Matthews, Ian R.;, Assignee: Imperial Chemical Industries PLC (Millbank, GB3) |
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Vasodialators 
