Hydrogenated diels-alder adducts of benzdiazepines
OF THE INVENTION The compounds of this invention have useful central nervous system stimulant activity in mammalian species, such as rats, dogs, etc., and can be used in the same manner as dextroamph... Read More
Inventors: Yale, Harry L.; Bristol, James A.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Method and composition for potentiating neuroleptic drugs
OF THE INVENTION Compounds having the foregoing structural formula such as, for example, .beta.-(4-chlorophenyl)-gammaaminobutyric acid and pharmaceutically acceptable salts thereof and pharmaceutica... Read More
Inventors: Fuxe, Kjell;, Assignee: Nelson Research & Development Company (Irvine, CA) |
Imidazo (1,2-B) isoquinoline derivatives
We claim: 1. A pharmaceutical dosage unit composition consisting essentially of an analgesic, anti-inflammatory, or anti-pyretic effective amount of a 5,10-dihydro-imidazo (1,2b) isoquinoline of the f... Read More
Inventors: Cookson, Ronald Frederick; Nowotnik, David Peter;, Assignee: Aspro-Nicholas Limited (Slough, EN) |
GRF analogs II
OF PREFERRED EMBODIMENTS The nomenclature used to define the peptides is that specified by Schroder & Lubke, "The Peptides", Academic Press (1965), wherein in accordance with conventional representat... Read More
Inventors: Vale, Jr., Wylie W.; Rivier, Jean E. F.;, Assignee: The Salk Institute for Biological Studies (San Diego, CA) |
GRF analogs VI
OF PREFERRED EMBODIMENTS The nomenclature used to define the peptides is that specified by Schroder & Lubke, "The Peptides", Academic Press (1965), wherein in accordance with conventional representat... Read More
Inventors: Rivier, Jean E. F.; Vale, Jr., Wylie W.;, Assignee: The Salk Institute for Biological Studies (San Diego, CA) |
3-Indolyl-3-phenyl-phthalides
We claim: 1. A phthalide compound of the formula ##STR22## wherein R.sub.5 and R.sub.6 independently of the other represent alkyl with 1 to 4 carbon atoms or benzyl, Z.sub.2 represents methyl or pheny... Read More
Inventors: Garner, Robert; Petitpierre, Jean C.;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Pyrido[2-1-b]quinazolin-ones and their methods of preparation
We claim: 1. 7-cyano-11-oxo-11H-pyrido[2,1-b]quinazoline. 2. 7-methyl-11-oxo-11H-pyrido[2,1-b]quinazoline. 3. 3-(ethoxycarbonyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid. 4. 11-oxo-11H-1,... Read More
Inventors: Schwender, Charles F.; Sunday, Brooks R.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Triazine compounds
I claim: 1. A compound of formula I ##STR32## wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by cyano, hydroxy, C.sub.1 -C.sub.4 alkoxy, cyclopropyl, methy... Read More
Inventors: Gass, Karl;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Stabilized catechol amine solutions
What is claimed is: 1. A physiologically useful catechol amine solution having enhanced stability comprising: in an aqueous medium from 0.1 to 10 weight percent of a catechol alkyl amine of from 8 to ... Read More
Inventors: Nite, Rebecca F.;, Assignee: Barnes-Hind Pharmaceuticals, Inc. (Sunnyvale, CA) |
Anesthetic/skin moisturizing composition and method of preparing same
In particular, it has been found that a long lasting, esthetically pleasing, medicated, moisturizing skin care composition is produced comprising forming an oil phase by dissolving a surface active a... Read More
Inventors: Geria, Navin M.;, Assignee: Warner-Lambert Co. (Morris Plains, NJ) |
7-oxabicycloheptane substituted amino prostaglandin analogs
What is claimed is: 1. A compound having the structure ##STR114## including all stereoisomers thereof, wherein n is 1 to 5; R.sup.1 is CO.sub.2 H, CO.sub.2 alkyl, or ##STR115## R.sup.2 is ##STR116## w... Read More
Inventors: Hall, Steven E.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Bis-(1,2,3-triazol-1-yl)-derivatives
What is claimed: 1. Bis-triazolyl derivatives of the formula: ##STR14## wherein: Y is a bivalent radical selected from: ##STR15## and ##STR16## X is a bivalent radical selected from: --O--; --S--; CR.... Read More
Inventors: Zanirato, Paolo; Pilati, Francesco; Chiolle, Antonio;, Assignee: Ausimont S.p.A. (Milan, IT) |
Plasticized polyvinyl chloride resin composition containing molybdenum flame retardant and antimony compound smoke suppressant agent
What is claimed is: 1. A flame resistant and smoke suppressed plasticized polyvinyl chloride polymer composition consisting essentially of a polyvinyl chloride polymer, from about 20 phr to about 100 ... Read More
Inventors: Moore, Fred W.; Tsigdinos, George A.;, Assignee: Amax Inc. (New York, NY) |
Androstanes
We claim: 1. A compound of the formula ##STR2## wherein: one of R.sup.1 and R.sup.2 is a methyl group, the other group being a C.sub.1-4 alkyl group, or R.sup.1 and R.sup.2 are both ethyl groups; R.su... Read More
Inventors: Phillipps, Gordon H.; Ewan, George B.;, Assignee: Glaxo Group Limited (London, GB2) |
10,11-Bis-(hydroxyalkyl) derivatives of cyproheptadine
OF THE INVENTION The preparation of the compounds of this invention (structures I, II, and III, above-depicted) is best described from inspection of the following reaction scheme: ##STR2## In words r... Read More
Inventors: Remy, David C.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
N-(substituted phenyl)-n-furanoyl-alanine methyl esters and their use in fungicidal composition and methods
I claim: 1. An anilide of the formula I ##STR9## wherein R represents hydrogen or methyl. 2. N-(1'-methoxycarbonyl-ethyl)-N-(furan-(2")-carbonyl)-2,6-dimethylaniline of the formula ##STR10## according... Read More
Inventors: Hubele, Adolf;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids
What is claimed is: 1. A compound of the formula: ##STR21## wherein X.sup.1 is hydrogen; lower alkyl; lower alkoxy; X.sup.2 is halogen or straight or branched chain lower alkyl; X.sup.3 is hydrogen; h... Read More
Inventors: Smith, Robert L.; Stokker, Gerald E.; Cragoe, Jr., Edward J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
5-Carboxy-phenylenebis(carbonylimino)benzene carboxylic and dicarboxylic acids and salts
We claim: 1. A compound of the formula: ##STR2## wherein R is selected from the group consisting of hydrogen and alkali metal; and with the proviso that the terminal phenyls may only be di-substituted... Read More
Inventors: Conrow, Ransom Brown; Poletto, John Frank; Bernstein, Seymour;, Assignee: American Cyanamid Company (Stamford, CT) |
Process for the preparation of 5-(4-aminobutyl) hydantoin and/or 1-ureido-5-aminocapronamide
We claim: 1. In a process for preparing 5-(4-amino-butyl) hydantoin including hydrogenating 5-(3-cyanopropyl) hydantoin in the liquid phase in the presence of ammonia and a hydrogenation catalyst cont... Read More
Inventors: Konijnenberg, Erik; Vandenbooren, Franciscus H. A. M. J.; Verheijen, Egidius J. M.;, Assignee: Stamicarbon, B.V. (Geleen, NL) |
Process for 2-chlorosulfinylazetidin-4-ones
According to the process of this invention, a 6-acylamido-2,2-dimethylpenam-3-carboxylic acid ester .alpha.-sulfoxide is heated at a temperature between about 70.degree. C. and about 120.degree. C. a... Read More
Inventors: Chou, Ta-Sen;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
1-Thiachromone-2-carboxylic acids and derivatives
We claim: 1. A member selected from the group consisting of a compound of the formula ##SPC10## wherein P, Q, R, and T are the same or different and each represents hydrogen, alkyl, hydroxy, alkoxy, h... Read More
Inventors: Hazard, Richard; King, John;, Assignee: Fisons Limited (EN) |
Complexes of heavy metal ions and polyfunctional organic ligands used as antimicrobial agents
What is claimed is: 1. A method of controlling microbes in a medium cnducive to microbial growth which comprises contacting said microbes or said medium with an effective antimicrobial amount of a met... Read More
Inventors: Maurer, Gerald L.; Shringarpurey, Sudhir K.;, Assignee: National Research Laboratories (Cincinnati, OH) |
Process for biological purification of waste water
The present invention relates to a new and novel process for the biological purification of waste water in which an aqueous suspension of the surplus sludge formed during the purification is hydrolyze... Read More
Inventors: Dassen, Bernardus H. N.;, Assignee: Stamicarbon, B.V. (Geleen, NL) |
Cathode materials
What is claimed is: 1. In the method of preparing cathode material comprising the steps of mixing polymeric material selected from the group consisting of P2VP, P4VP, and mixtures thereof with a quant... Read More
Inventors: Phillips, Gary M.; Untereker, Darrel F.;, Assignee: Medtronic, Inc. (Minneapolis, MN) |
Water purification system
I claim: 1. A portable water purifying apparatus for treating contaminated water to provide drinking water solely from the passage of said contaminated water through said apparatus comprising an elong... Read More
Inventors: Gartner, William J.;, Assignee: |
Halogenated ethylene/vinyl acetate/isobutylene terpolymers
OF THE INVENTION The EVAI terpolymers of the present invention are basically formed in accordance with known prior art techniques for the free radical catalytic formation of EVA copolymers at high te... Read More
Inventors: Pritchett, Ervin G.; Hoyt, John M.;, Assignee: National Distillers and Chemical Corporation (New York, NY) |
O-ethyl-S-n-propyl-O-[pyridaz-(6)-on-(3)-yl]-thionothiolphosphoric acid esters
Whaat is claimed is: 1. An O-ethyl-S-n-propyl-O-[pyridaz-(6)-on-(3)-yl]-thiono-thiolphosphoric acid ester of the formula ##SPC9## in which R.sup.1 is hydrogen, alkyl with 1 to 6 carbon atoms, or alkyl... Read More
Inventors: Hofer, Wolfgang; Maurer, Fritz; Riebel, Hans-Jochem; Rohe, Lothar; Hammann, Ingeborg; Stendel, Wilhelm;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DT) |
4-(Polyalkoxyphenyl)-2-pyrrolidones
What is claimed is: 1. A pharamaceutical composition for the treatment of neurological and psychic disorders responsive to chlorpromazine therapy and characterized by one or more of the symptoms of an... Read More
Inventors: Schmiechen, Ralph; Horowski, Reinhard; Palenschat, Dieter; Paschelke, Gert; Wachtel, Helmut; Kehr, Wolfgang;, Assignee: Schering Aktiengesellschaft (Berlin & Bergkamen, DT) |
Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid, compositions and use
OF THE INVENTION The term "lower alkyl" as used herein contemplates straight chain alkyl radicals containing from one to six carbon atoms and branched chain alkyl radicals containing from three to fo... Read More
Inventors: Mobilio, Dominick; Demerson, Christopher A.; Humber, Leslie G.;, Assignee: American Home Products Corporation (New York, NY) |
Antihypertensive 4-thiazolidinecarboxylic acids
OF THE INVENTION This invention relates to derivatives of 4-thiazolidinecarboxylic acid and salts thereof which are useful as antihypertensive agents. These compounds are represented by the formula #... Read More
Inventors: Iwao, Junichi; Oya, Masayuki; Baba, Toshio; Iso, Tadashi; Chiba, Takehisa;, Assignee: Santen Pharmaceutical Co., Ltd. (Osaka, JP) |
Vasodialators 
