Prostaglandins and methods of making same
OF THE INVENTION Prostaglandin E.sub.1, which may be depicted structurally as ##SPC1## Is one of a group of naturally occurring compounds known generally as prostaglandins. These prostaglandins have ... Read More
Inventors: Wendler, Norman L.; Taub, David;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Process for the manufacture of 3-methylene-cepham compounds
What we claim is: 1. Process for the manufacture of .alpha.-7.beta.-amino-3-methylene-cephem-4-carboxylic acid compounds of the formula ##STR10## where R.sub.1.sup.a represents hydrogen or 5-aminoadip... Read More
Inventors: Fechtig, Bruno;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Method of continuously producing .gamma.-butyrolactams
We claim: 1. A liquid-phase process for continuously producing .gamma.-butyrolactams which comprises passing a .gamma.-butyrolactone selected from the group consisting of .gamma.-butyrolactone and .ga... Read More
Inventors: Himmele, Walter; Hofmann, Ernst; Hoffmann, Herwig; Plass, Reinhold;, Assignee: Badische Anilin- & Soda-Fabrik Aktiengesellschaft (Ludwigshafen (Rhine), DT) |
Sectional boat
OF THE INVENTION The apparatus of this invention is a sectional boat which has its sections connected together with novel attachments dividing the stress generated at the attaching face between the a... Read More
Inventors: Grind, Robert E.;, Assignee: |
Stabilization of internally administered pancreatic lipase
What is claimed is: 1. An acid stable, lipase containing medicament in tablet form, for treating pancreatic insufficiency comprising: a. from about 10 to about 34% by weight of an active lipase having... Read More
Inventors: Boettner, Fred E.; Neubeck, Clifford E.;, Assignee: Rohm and Haas Company (Philadelphia, PA) |
Cholesterol matrix delivery system for sustained release of macromolecules
OF THE INVENTION The active agent delivery systems of this invention provide several important advantages over previously known delivery systems. The most important advantage, as discussed above, is ... Read More
Inventors: Kent, John S.;, Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Waste-containment garment having integrally protected adhesive fasteners
OF THE INVENTION An exemplary garment which is an embodiment of the present invention is shown in FIG. 1 to be an elasticized disposable diaper insert 20 which comprises elasticized leg cuffs 21 and ... Read More
Inventors: Joffe, Frederick M.;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Cephalosporin derivatives having at the 3-position of the cephem ring a heterocyclic thiomethyl group with a carboxy or sulfo group and at the 7-position of the cephem ring an .alpha.-heterocylic acylaminophenyl-acetamide group
OF THE INVENTION The present invention relates to novel cephalosporin derivatives. More particularly, the invention relates to novel cephalosporin derivatives represented by the formula ##STR1## wher... Read More
Inventors: Murakami, Masuo; Isaka, Ichiro; Kawahara, Norio; Iwanami, Masaru; Fujimoto, Masaharu; Maeda, Tetsuya; Shibanuma, Tadao; Nagano, Yoshinobu;, Assignee: Yamanouchi Pharmaceutical Co., Ltd. (Tokyo, JA) |
1,3-Bis-(.beta.-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine-na phthalene-1,5-disulphonate
What we claim is: 1. 1,3-bis-(.beta .-ethylhexyl)-5-nitro-5-methyl-hexahydropyrimidine-naphthalene-1,5-disulpho nate of the formula ##STR4##
Description:
The invention relates to an indu... Read More
Inventors: Lange, Fritz-Walter; Haffner, Gert; Muller, Jens;, Assignee: MEDITEST Institut fur medizinisch pharmazeutische Untersuchungen GmbH (Neu-Ulm, DT) |
Ureidoacetamido-penicillins
What is claimed is: 1. A compound selected from the group consisting of a penicillin of the formula: ##EQU26## and the pharmaceutically acceptable salts thereof, wherein the carbon atom designated * c... Read More
Inventors: Konig, Hans-Bodo; Schrock, Wilfried; Disselnkotter, Hans; Metzger, Karl Georg;, Assignee: Bayer Aktiengesellschaft (DT) |
Novel penicillins and cephalosporins and process for producing the same
What is claimed is: 1. An acid halide, acid azide, acid cyanide, cyanomethyl ester or trichloromethyl ester of a compound of the formula, ##STR562## wherein A is a hydrogen atom or a C.sub.1-12 alkyl,... Read More
Inventors: Saikawa, Isamu; Takano, Shuntaro; Yoshida, Chosaku; Takashima, Okuta; Momonoi, Kaishu; Kuroda, Seietsu; Komatsu, Miwako; Yasuda, Takashi; Kodama, Yutaka;, Assignee: Toyama Chemical Co., Ltd. (Tokyo, JA) |
Substituted arylaliphatic acids
What is claimed is: 1. A substituted arylaliphatic acid represented by the formula ##STR13## in which X is a nitro or amino group. 2. A compound in accordance with claim 1, wherein X is amino. 3. A ph... Read More
Inventors: Szarvasi, Etienne; Festal, Didier;, Assignee: Lipha, Lyonnaise Industrielle Pharmaceutique (Lyon, FR) |
2-Amino-4-(4-benzyloxyphenyl)thiazoles, and their use in hyperlipemia
What is claimed is: 1. A compound of the formula: ##STR9## wherein X is hydrogen, halogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R is hydrogen, alkyl having 1 to 4 carbon atoms, alkenyl... Read More
Inventors: Kawamatsu, Yutaka; Sohda, Takashi; Imai, Yoshio;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP) |
1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid esters and a method of use for combating insects or acarids
What is claimed is: 1. A method of combating insect or acarid pests which comprises applying to the pests or a habitat thereof an insecticidally or acaricidally effective amount of 1-methyl-3-2'-buten... Read More
Inventors: Tamura, Saburo; Saito, Junichi; Kudamatsu, Akio; Ishino, Yoji; Goto, Toshio;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DT) |
Feed for poultry
OF THE INVENTION It has been discovered that a specially formulated poultry feed results in egg production having a substantially lower cholesterol content. This feed has been found to have general u... Read More
Inventors: Klein, Samuel;, Assignee: |
Substituted oxazoles and thiazoles as herbicides
What is claimed is: 1. The method of combatting weeds in a locus containing weeds comprising applying to the locus a herbicidally effective amount of a compound of the formula: ##STR18## wherein R.deg... Read More
Inventors: Jackson, Thomas E.;, Assignee: Sandoz, Inc. (E. Hanover, NJ) |
N-Carbamoyl ethyl oxanilates
OF THE INVENTION In the practice of the present invention, the novel compounds of the present invention are manufactured by reacting the properly selected 1,3,3-trisubstituted urea with sodium hydrid... Read More
Inventors: Gaughan, Edmund J.;, Assignee: Stauffer Chemical Company (Westport, CT) |
N.sup.2 -dansyl-L-arginine derivatives, and the pharmaceutically acceptable acid addition salts thereof
OF THE PREFERRED EMBODIMENTS In the formula (I), R is preferably alkoxy of 1-8 carbon atoms, aralkyloxy of 7-9 carbon atoms, alkenyloxy of 3-6 carbon atoms, alkynyloxy of 3-6 carbon atoms, cyclohexyl... Read More
Inventors: Okamoto, Shosuke; Kikumoto, Ryoji; Tamao, Yoshikuni; Tonomura, Shinji; Ohkubo, Kazuo;, Assignee: Mitsubishi Chemical Industries Ltd. (Tokyo, JA) |
Method for treating anxiety in mammals
OF THE INVENTION The active compounds of the present invention are generally obtainable as white to pale yellow crystalline materials having characteristic melting points and absorption spectra and w... Read More
Inventors: Allen, Jr., George Rodger; Hanifin, Jr., John William; Moran, Daniel Bryan; Albright, Jay Donald;, Assignee: American Cyanamid Company (Stamford, CT) |
Method for non-invasive detection of ocular melanoma
The above objects are achieved and the disadvantages of the prior art are overcome by an apparatus for diagnosing ocular cancer which comprises two radiation detectors and means for mounting the two d... Read More
Inventors: Lambrecht, Richard M.; Packer, Samuel;, Assignee: The United States of America as represented by the United States (Washington, DC) |
Perinone dyestuffs
I claim: 1. Perinone dyestuff having the formula ##SPC16## in which one of R.sub.2 ' and R.sub.3 ' is hydrogen and the other --CN or --CO.sub.2 C.sub.p H.sub.2p.sub.+1 ; one of R.sub.4 ' and R.sub.5 '... Read More
Inventors: Kruckenberg, Winfried;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DT) |
Synergistic pesticidal compositions
We claim: 1. An arthropodicidal composition containing as active ingredients (I) a pyrethroid of the formula ##STR4## the weight ratio of I:II being from about 1:10 to 1:40. 2. A composition according... Read More
Inventors: Behrenz, Wolfgang; Schutte, Manfred;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
2-Piperazinyl-6,7-dimethoxyquinazolines
What is claimed is: 1. A compound having the formula ##STR11## or a pharmaceutically acceptable salt thereof wherein R is amino or hydrazino; R.sub.1 is cycloalkyl having 3 to 8 ring carbon atoms incl... Read More
Inventors: Matier, William Lesley; Catt, John David;, Assignee: Mead Johnson & Company (Evansville, IN) |
Process for preparing quinazolines
OF THE INVENTION As indicated hereinabove, the instant invention is concerned with a process for preparing compounds of formula I ##STR2## wherein X is halogen selected from the group consisting of c... Read More
Inventors: Crenshaw, Ronnie Ray; Luke, George Michael; Partyka, Richard Anthony;, Assignee: Bristol-Myers Company (New York, NY) |
Process for preparing 2,4-dihaloquinazolines
OF THE INVENTION As indicated hereinabove, the instant invention is concerned with a process for preparing a compound of formula I ##STR6## wherein X is halogen selected from the group consisting of ... Read More
Inventors: Crenshaw, Ronnie Ray; Luke, George Michael; Partyka, Richard Anthony;, Assignee: Bristol-Myers Company (New York, NY) |
Levulinic acid salt
What is claimed is: 1. A levulinic acid addition salt of 4-amino-6,7-dimethoxy-2[4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl]pipera zin-1-yl)-quinazoline wherein the base to acid ratio comprises one m... Read More
Inventors: Kaplan, Murray A.; Granatek, Alphonse P.;, Assignee: Bristol-Myers Company (New York, NY) |
Process for the preparation of imidazo[2,1-b]quinazolinones
We claim: 1. A process for the preparation of a compound of the formula ##STR16## wherein R.sup.1 and R.sup.2 are each individually selected from hydrogen, (lower)alkyl, (lower)alkoxy, (lower)alkylthi... Read More
Inventors: Crenshaw, Ronnie R.; Montzka, Thomas A.;, Assignee: Bristol-Myers Company (New York, NY) |
Aldose reductase inhibition by 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-ac etic acid
OF THE INVENTION 5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-aceti c acid forms salts with suitable therapeutically acceptable inorganic and organic bases. These derived sal... Read More
Inventors: Dvornik, Dushan M.; Simard-Duquesne, Nicole;, Assignee: Ayerst, McKenna & Harrison Inc. (Montreal, CA) |
8,10-Dideazaminopterins
We claim: 1. A compound of the formula ##STR6## where R is a hydrogen or alkyl of 1 to about 8 carbon atoms, and pharmaceutically acceptable salts thereof. 2. The compound of claim 1 wherein R is hydr... Read More
Inventors: DeGraw, Joseph I.; Kelly, Lawrence F.; Sirotnak, Francis M.;, Assignee: SRI International (Menlo Park, CA) |
Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities
What is claimed is: 1. A compound of the formula (1): ##STR7## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is C.sub.1-6 alkyl or C.sub.2-6 alkenyl, and R.sup.2 is hydrogen or hydrox... Read More
Inventors: Coates, William J.;, Assignee: Smith Kline & French Laboratories Limited (Welwyn Garden City, GB2) |
Vasodialators 
